XB-ART-20508
Can J Physiol Pharmacol
1994 Dec 01;7212:1586-8. doi: 10.1139/y94-228.
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Inhibition by antidepressants of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes.
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Effects of antidepressive drugs on glibenclamide-sensitive K+ currents were investigated using follicle-enclosed Xenopus oocytes. Antidepressive drugs, imipramine, desipramine, and amitriptyline, inhibited the K+ currents with IC50 (microM) values of 35.4, 39.7, and 87.7, respectively. The K+ current blocking actions of antidepressants appear to be associated with their local anesthetic related structures.
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