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XB-ART-20405
Life Sci 1995 Jan 01;5722:PL351-6. doi: 10.1016/0024-3205(95)02188-o.
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Reduction of acetylcholine-activated current by low concentrations of extracellular adenosine 5'-triphosphate.

Nakazawa K , Ito K , Koizumi S , Ohno Y , Inoue K .


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Effects of adenosine 5'-triphosphate (ATP) on ionic currents activated by acetylcholine (ACh) were investigated using rat pheochromocytoma PC12 cells and Xenopus oocytes expressing nicotinic receptors. In PC12 cells, ATP (10 nM to 1 microM) inhibited an inward current activated by ACh in not all but about 60% of cell batches. The ACh-activated current was also inhibited by ATP in Xenopus oocytes and, with a subunit combination of alpha 3 plus beta 4, the inhibition was observed at concentration as low as 100 fM. Uridine 5'-triphosphate (UTP) induced a similar inhibition of the ACh-activated current both in PC12 cells and Xenopus oocytes. These and other properties suggest that the current reduction by ATP is not mediated through conventional P2-purinoceptors.

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