XB-ART-20217
Prog Cell Cycle Res
1995 Jan 01;1:265-70. doi: 10.1007/978-1-4615-1809-9_21.
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Phosphorylation of elongation factor-1 (EF-1) by cdc2 kinase.
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Elongation factor-1 (EF-1) is a major substrate for cdc2 kinase in Xenopus oocytes. The guanine-nucleotide exchange factor EF-1 beta gamma delta, appears to have a highly complex macromolecular structure containing several GTP/GDP exchange proteins, valyl-tRNA synthetase, and a putative anchoring protein EF-1 gamma. During meiotic cell division, the factor becomes phosphorylated by cdc2 kinase, not only on EF-1 gamma, but also on two different phospho-acceptors on EF-1 delta. Phosphorylation is concomitant with changes in protein synthesis in vivo. Xenopus oocytes, and potentially all cells, contain a multitude of heteromeric forms of the complex which postulates that EF-1 beta gamma delta is not a "house keeping" factor but a sophisticated regulatory element.
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Species referenced: Xenopus
Genes referenced: cdk1 mt-tr pold1 trna