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XB-ART-20148
Nihon Yakurigaku Zasshi 1995 Feb 01;1052:53-61. doi: 10.1254/fpj.105.53.
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[Pharmacology of glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes].

Sakuta H .


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Follicle-enclosed Xenopus oocytes have endogenous glibenclamide-sensitive K+ channels that can be activated by K+ channel openers. Since the follicle-enclosed Xenopus oocytes can be easily voltage-clamped, the K+ channels are used as a model of the ATP/glibenclamide-sensitive K+ channels. So far, the effects of calmodulin antagonists, antiarrhythmics, anesthetics, antidepressants, histamine H1-receptor antagonists, imidazolines and several hormones on the K+ channels of the oocytes have been reported. The pharmacological data on the K+ channels obtained from the oocyte-system may contribute to our understanding of the regulatory mechanism and physiological role of the ATP/glibenclamide-sensitive K+ channels.

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???displayArticle.link??? Nihon Yakurigaku Zasshi