XB-ART-20131
Sheng Li Xue Bao
1995 Feb 01;471:1-10.
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[Amino acid neurotransmitter receptors of carp brain expressed in amphibian oocytes].
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GABA receptor and inotropic glutamate receptors were expressed in amphibian oocytes and studied with the voltage-clamp technique and pharmacological method after injection of mRNA from carp (Carassius carassius) brains. It was found that about 90% of the response to GABA was mediated by GABAA receptor, but there was also about 10% of the response which was insensitive to bicuculline, a selective antagonist to GABAA receptor, baclofen, a selective agonist to GABAB receptor, had no effect on the injected oocytes. These observations suggest the existence of GABAC receptor. Subtypes of glutamate receptors, including NMDA subtype, KA/AMPA subtype and metabotropic glutamate receptors were also expressed and the dose-response relations were studied. Furthermore, we found that NMDA competitively suppressed the current response to KA, suggesting that NMDA probably was a weak antagonist of the KA/AMPA receptor.
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Species referenced: Xenopus laevis
Genes referenced: gabarap mindy3