Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-19986
Science 1995 Mar 10;2675203:1491-4.
Show Gene links Show Anatomy links

Glutamate receptor RNA editing in vitro by enzymatic conversion of adenosine to inosine.

Rueter SM , Burns CM , Coode SA , Mookherjee P , Emeson RB .


???displayArticle.abstract???
RNA encoding the B subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype of ionotropic glutamate receptor (GluR-B) undergoes a posttranscriptional modification in which a genomically encoded adenosine is represented as a guanosine in the GluR-B complementary DNA. In vitro editing of GluR-B RNA transcripts with HeLa cell nuclear extracts was found to result from an activity that converts adenosine to inosine in regions of double-stranded RNA by enzymatic base modification. This activity is consistent with that of a double-stranded RNA-specific adenosine deaminase previously described in Xenopus oocytes and widely distributed in mammalian tissues.

???displayArticle.pubmedLink??? 7878468
???displayArticle.link??? Science
???displayArticle.grants??? [+]

Species referenced: Xenopus
Genes referenced: ada ada.2