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XB-ART-1965
FEBS Lett 2005 May 09;57912:2727-30. doi: 10.1016/j.febslet.2005.03.082.
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Scallop DMT functions as a Ca2+ transporter.

Toyohara H , Yamamoto S , Hosoi M , Takagi M , Hayashi I , Nakao K , Kaneko S .


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We identified a DMT (divalent metal transporter) homologous protein that functions as a Ca(2+) transporter. Scallop DMT cDNA encodes a 539-amino-acid protein with 12 putative membrane-spanning domains and has a consensus transport motif in the fourth extracellular loop. Since its mRNA is significantly expressed in the gill and intestine, it is assumed that scallop DMT transports Ca(2+) from seawater by the gill and from food by the intestine. Scallop DMT lacks the iron-responsive element commonly found in iron-regulatory proteins, suggesting that it is free of the post-transcriptional regulation from intracellular Fe(2+) concentration. Scallop DMT distinctly functions as a Ca(2+) transporter unlike other DMTs, however, it also transports Fe(2+) and Cd(2+) similar to them.

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