XB-ART-19521
Thromb Haemost
1995 Jul 01;741:529-33.
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Organization of the provisional fibronectin matrix: control by products of blood coagulation.
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Assembly of fibronectin into the provisional fibrillar matrix of embryonic tissues and wounds is a complicated process by which the intracellular cytoskeleton determines the pattern of assembly of extracellular matrix and vice versa. Assembly is restricted to dimeric fibronectin molecules with intact N-terminal modules and occurs at specialized cell surface sites. Cellular display of assembly sites is labile and requires that cells be under tension and have functional beta 1 integrins. Lysophosphatidic acid (LPA) an intermediate for de novo lipid biosynthesis and a product of platelet activation, is a powerful serum modulator of fibronectin assembly.
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Species referenced: Xenopus laevis
Genes referenced: fn1