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XB-ART-19507
Gene 1995 Jul 04;1592:215-8. doi: 10.1016/0378-1119(95)00145-v.
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Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA.

Drew PD , Nagle JW , Canning RD , Ozato K , Biddison WE , Becker KG .


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We report here the nucleotide sequence of a clone, C2H2-34.10, isolated from a human brain cDNA library using degenerate oligodeoxyribonucleotide hybridization. C2H2-34.10 has extensive homology to the Xenopus laevis 5S DNA/RNA-binding protein, TFIIIA. The deduced amino acid (aa) sequence of the human clone gives a protein of 363 aa with identity to TFIIIA from both X. laevis (57%) and Rana pipiens (59%). This human clone contains nine C2H2-type zinc fingers like frog TFIIIA. Northern blot analysis indicates that the C2H2-34.10 RNA is expressed in human ovary, as well as human neuronal cell lines.

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Species referenced: Xenopus laevis
Genes referenced: gtf3a