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XB-ART-19446
Brain Res Mol Brain Res 1995 Aug 01;321:166-70. doi: 10.1016/0169-328x(95)00077-6.
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Opioid mu- and kappa-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes.

Ueda H , Miyamae T , Fukushima N , Takeshima H , Fukuda K , Sasaki Y , Misu Y .


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In the Xenopus oocytes expressing mu- or kappa-opioid receptors, agonist-induced currents were observed only when the oocyte was coinjected with Gi1 alpha RNA and pretreated with K-252a, a potent inhibitor of protein kinases. The evoked currents were abolished by intracellular injection of EGTA or inositol 1,4,5-trisphosphate and the current-voltage relationship revealed that they are mediated through typical calcium-dependent chloride channels. These findings suggest that the mu- and kappa-receptors mediate phospholipase C activation through Gi1 alpha, and that these receptor mechanisms including downstream signalings might be inhibited by phosphorylation in vivo in the Xenopus oocyte.

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