XB-ART-19235
Science
1995 Sep 29;2695232:1883-5.
Show Gene links
Show Anatomy links
FFA-1, a protein that promotes the formation of replication centers within nuclei.
???displayArticle.abstract???
In the nuclei of eukaryotic cells, initiation of DNA replication occurs at a discrete number of foci. One component of these foci is the DNA replication factor RP-A. Here, the process leading to the association of RP-A with foci was reconstituted with cytosolic fractions derived from Xenopus eggs. With the use of this fractionated system, a 170-kilodalton protein required for the assembly of RP-A into foci was identified and purified. The protein appears to be an integral component of the foci at which replication of DNA is initiated in eukaryotic nuclei.
???displayArticle.pubmedLink??? 7569932
???displayArticle.link??? Science
???displayArticle.grants???
Species referenced: Xenopus
Genes referenced: rpa1 wrn