XB-ART-19224
Dev Biol
1995 Oct 01;1712:340-51. doi: 10.1006/dbio.1995.1286.
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Calcium channel subtypes and intracellular calcium stores modulate electric field-stimulated and -oriented nerve growth.
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In culture, embryonic spinal neurites from Xenopus laevis show striking growth responses to steady dc electric fields, at a time when endogenous electric fields of similar size impinge on the developing nervous system. A high proportion of cultured neurites reorient, with both turning and branching directed cathodally. Neurite growth rates are increased and growth is differential (faster cathodally than anodally). Voltage-dependent calcium channels and calcium release from intracellular stores are shown to control these events. However, the pharmacological sensitivities of these phenomena differ, indicating different control mechanisms.
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