Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Plant Cell
1995 Dec 01;712:2175-85. doi: 10.1105/tpc.7.12.2175.
Show Gene links
Show Anatomy links
Plant inositol monophosphatase is a lithium-sensitive enzyme encoded by a multigene family.
Gillaspy GE
,
Keddie JS
,
Oda K
,
Gruissem W
.
???displayArticle.abstract???
myo-Inositol monophosphatase (IMP) is a soluble, Li(+)-sensitive protein that catalyzes the removal of a phosphate from myo-inositol phosphate substrates. IMP is required for de novo inositol synthesis from glucose 6-phosphate and for breakdown of inositol trisphosphate, a second messenger generated by the phosphatidylinositol signaling pathway. We cloned the IMP gene from tomato (LeIMP) and show that the plant enzyme is encoded by a small gene family. Three different LeIMP cDNAs encode distinct but highly conserved IMP enzymes that are catalytically active in vitro. Similar to the single IMP from animals, the activities of all three LeIMPs are inhibited by low concentrations of LiCl. LeIMP mRNA levels are developmentally regulated in seedlings and fruit and in response to light. Immunoblot analysis detected three proteins of distinct molecular masses (30, 29, and 28 kD) in tomato; these correspond to the predicted molecular masses of the LeIMPs encoded by the genes. Immunoreactive proteins in the same size range are also present in several other plants. Immunolocalization studies indicated that many cell types within seedlings accumulate LeIMP proteins. In particular, cells associated with the vasculature express high levels of LeIMP protein; this may indicate a coordinate regulation between phloem transport and synthesis of inositol. The presence of three distinct enzymes in tomato most likely reflects the complexity of inositol utilization in higher plants.
Berridge,
Inositol trisphosphate and diacylglycerol: two interacting second messengers.
1987, Pubmed
Berridge,
Inositol trisphosphate and diacylglycerol: two interacting second messengers.
1987,
Pubmed
Berridge,
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands.
1982,
Pubmed
Biffen,
Reduction in the level of intracellular myo-inositol in cultured soybean (Glycine max) cells inhibits cell division.
1990,
Pubmed
Bohnert,
Adaptations to Environmental Stresses.
1995,
Pubmed
Bone,
Structure of inositol monophosphatase, the putative target of lithium therapy.
1992,
Pubmed
Busa,
Lithium-induced teratogenesis in frog embryos prevented by a polyphosphoinositide cycle intermediate or a diacylglycerol analog.
1989,
Pubmed
,
Xenbase
Cockroft,
Inositol deficiency increases the susceptibility to neural tube defects of genetically predisposed (curly tail) mouse embryos in vitro.
1992,
Pubmed
Eisenberg,
D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis.
1967,
Pubmed
Fabiny,
Ammonium transport in Escherichia coli: localization and nucleotide sequence of the amtA gene.
1991,
Pubmed
Geever,
DNA sequence, organization and regulation of the qa gene cluster of Neurospora crassa.
1989,
Pubmed
Gillaspy,
Fruits: A Developmental Perspective.
1993,
Pubmed
Gläser,
Salt tolerance and methionine biosynthesis in Saccharomyces cerevisiae involve a putative phosphatase gene.
1993,
Pubmed
Gumber,
Further Studies on myo-Inositol-1-phosphatase from the Pollen of Lilium longiflorum Thunb.
1984,
Pubmed
Hallcher,
The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.
1980,
Pubmed
Hawkins,
Molecular organisation of the quinic acid utilization (QUT) gene cluster in Aspergillus nidulans.
1988,
Pubmed
Hirayama,
A gene encoding a phosphatidylinositol-specific phospholipase C is induced by dehydration and salt stress in Arabidopsis thaliana.
1995,
Pubmed
Inhorn,
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.
1987,
Pubmed
Johnson,
1 L-myo-Inositol 1-Phosphate Synthase from Arabidopsis thaliana.
1995,
Pubmed
Johnson,
The arabidopsis thaliana myo-inositol 1-phosphate synthase (EC 5.5.1.4).
1994,
Pubmed
Joseph,
Hydrolysis of inositol phosphates by plant cell extracts.
1989,
Pubmed
Maslanski,
Lithium-sensitive production of inositol phosphates during amphibian embryonic mesoderm induction.
1992,
Pubmed
,
Xenbase
Matsuhisa,
Inositol monophosphatase activity from the Escherichia coli suhB gene product.
1995,
Pubmed
Murguía,
A salt-sensitive 3'(2'),5'-bisphosphate nucleotidase involved in sulfate activation.
1995,
Pubmed
Narita,
Tomato hydroxymethylglutaryl-CoA reductase is required early in fruit development but not during ripening.
1989,
Pubmed
Neuwald,
Diverse proteins homologous to inositol monophosphatase.
1991,
Pubmed
Nieuwkoop,
The organization center of the amphibian embryo: its origin, spatial organization, and morphogenetic action.
1973,
Pubmed
Parthasarathy,
Biochemical and molecular properties of lithium-sensitive myo-inositol monophosphatase.
1994,
Pubmed
Peters,
Lithium ions induce prestalk-associated gene expression and inhibit prespore gene expression in Dictyostelium discoideum.
1989,
Pubmed
Ragan,
The dephosphorylation of inositol 1,4-bisphosphate to inositol in liver and brain involves two distinct Li+-sensitive enzymes and proceeds via inositol 4-phosphate.
1988,
Pubmed
Sasaki,
myo-Inositol Synthesis from [1-H]Glucose in Phaseolus vulgaris L. during Early Stages of Germination.
1986,
Pubmed
Schuster,
Chloroplast mRNA 3' end processing requires a nuclear-encoded RNA-binding protein.
1991,
Pubmed
Trewavas,
Signal transduction in plant cells.
1991,
Pubmed
Vernon,
A novel methyl transferase induced by osmotic stress in the facultative halophyte Mesembryanthemum crystallinum.
1992,
Pubmed
Wreggett,
Inositol monophosphatase is a highly conserved enzyme having localized structural similarity to both glycerol 3-phosphate dehydrogenase and haemoglobin.
1992,
Pubmed
,
Xenbase
Yamamoto,
An Arabidopsis cDNA related to animal phosphoinositide-specific phospholipase C genes.
1995,
Pubmed
York,
Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase.
1990,
Pubmed