XB-ART-18627
Neuroreport
1996 Jan 31;72:477-80. doi: 10.1097/00001756-199601310-00024.
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Presynaptic and Ca(2+)-independent PKC subspecies modulates NMDAR1 current.
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We have studied the properties of the protein kinase C (PKC) subspecies that modulates the NMDA receptor (NMDAR1). The current through homomeric NMDAR1 expressed in Xenopus oocytes was increased by 200-500% by phorbol ester and also by activation of a metabotropic glutamate receptor (mGluR1) expressed in the same oocytes. This potentiation of the NMDAR1 current was not inhibited by the intracellular injection of EGTA. Intracellular injection of epsilon-PKC, a presynaptic PKC subspecies, potentiated the NMDAR1 current more efficiently that did the Ca(2+)-dependent gamma-PKC, a postsynaptic subspecies of the enzyme. Our findings suggested that the presynaptic NMDA receptor could be potentiated in a Ca(2+)-independent manner by the activation of presynaptic PKC subspecies.
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Species referenced: Xenopus laevis
Genes referenced: grin1