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XB-ART-18516
FEBS Lett 1996 Feb 26;3811-2:98-102.
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Expression and functional characterization of a melatonin-sensitive receptor in Xenopus oocytes.

Fischer B , Musshoff U , Fauteck JD , Madeja M , Wittkowski W , Speckmann EJ .


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Melatonin (MEL) plays a central role in the regulation of seasonal cycles and in the control of circadian rhythms in mammals. Functional MEL-sensitive receptors were expressed in Xenopus laevis oocytes following injection of poly (A)+ RNA from rat brain. Administration of 0.1-100 micromol/l MEL to voltage-clamped oocytes (holding potential: -70 mV) elicited oscillatory inward currents (reversal potential: -24 mV) which could be blocked by 9-anthracenecarboxylic acid and caffeine. After preincubation with pertussis toxin (PTX) the MEL response disappeared. The expressed MEL-sensitive receptor probably activates Ca(2+)-dependent chloride currents via a PTX-sensitive G protein and the phosphoinositol pathway.

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Species referenced: Xenopus laevis
Genes referenced: mtnr1al