Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Pflugers Arch
1996 Mar 01;4315:736-40. doi: 10.1007/bf02253837.
Show Gene links
Show Anatomy links
Activation of ATP-sensitive potassium channels in follicle-enclosed xenopus oocytes by the epileptogenic agent pentylenetetrazol.
Klöcker N
,
Musshoff U
,
Madeja M
,
Speckmann EJ
.
???displayArticle.abstract???
For further investigation of the epileptogenic properties of pentylenetetrazol (PTZ), membrane currents elicited by PTZ were analysed in native Xenopus oocytes. PTZ elicited a sequence of membrane currents. Two inward currents have been described to be due to a decrease in potassium permeability and an increase in chloride permeability. Experiments performed up to 3 days after preparation of the oocytes showed that PTZ is also able to activate an outward current. This current is: (1) reversed near the potassium equilibrium potential, (2) associated with a decrease in membrane resistance, (3) reduced by tetraethylammonium and caesium, (4) abolished by defolliculation, and (5) blocked by glibenclamide. Thus, the current can be interpreted to be due to an activation of ATP-sensitive potassium (KATP) channels located in the follicle cells. An activation of KATP channels by PTZ may contribute to termination and re-initiation of seizure activity.
BARTH,
Differentiation of cells of the Rana pipiens gastrula in unconditioned medium.
1959, Pubmed
BARTH,
Differentiation of cells of the Rana pipiens gastrula in unconditioned medium.
1959,
Pubmed
Ben Ari,
Effect of glibenclamide, a selective blocker of an ATP-K+ channel, on the anoxic response of hippocampal neurones.
1989,
Pubmed
Bingmann,
Actions of pentylenetetrazol (PTZ) on CA3 neurons in hippocampal slices of guinea pigs.
1986,
Pubmed
Bloms-Funke,
Decrease and increase of responses to glutamate receptor agonists in RNA-injected Xenopus oocytes by the epileptogenic agent pentylenetetrazol: dependence on the agonist concentration.
1994,
Pubmed
,
Xenbase
Browne,
Oocyte-follicle cell gap junctions in Xenopus laevis and the effects of gonadotropin on their permeability.
1979,
Pubmed
,
Xenbase
Caspers,
Cerebral pO 2 , pCO 2 and pH: changes during convulsive activity and their significance for spontaneous arrest of seizures.
1972,
Pubmed
Dascal,
The use of Xenopus oocytes for the study of ion channels.
1987,
Pubmed
,
Xenbase
Dumont,
Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.
1972,
Pubmed
,
Xenbase
Edwards,
The pharmacology of ATP-sensitive potassium channels.
1993,
Pubmed
Hartung,
Differential effects of pentylenetetrazole on ion currents of Aplysia neurones.
1987,
Pubmed
Honoré,
Two different types of channels are targets for potassium channel openers in Xenopus oocytes.
1991,
Pubmed
,
Xenbase
Honoré,
Hormone-regulated K+ channels in follicle-enclosed oocytes are activated by vasorelaxing K+ channel openers and blocked by antidiabetic sulfonylureas.
1991,
Pubmed
,
Xenbase
Honoré,
Single-channel properties and regulation of pinacidil/glibenclamide-sensitive K+ channels in follicular cells from Xenopus oocyte.
1993,
Pubmed
,
Xenbase
Klee,
Strychnine- and pentylenetetrazol-induced changes of excitability in Aplysia neurons.
1973,
Pubmed
Leweke,
Effects of pentetrazol on neuronal activity and on extracellular calcium concentration in rat hippocampal slices.
1990,
Pubmed
Macdonald,
Pentylenetetrazol and penicillin are selective antagonists of GABA-mediated post-synaptic inhibition in cultured mammalian neurones.
1977,
Pubmed
Madeja,
Potassium currents in epilepsy: effects of the epileptogenic agent pentylenetetrazol on a cloned potassium channel.
1994,
Pubmed
,
Xenbase
Madeja,
A concentration-clamp system allowing two-electrode voltage-clamp investigations in oocytes of Xenopus laevis.
1991,
Pubmed
,
Xenbase
Madeja,
Membrane currents elicited by the epileptogenic drug pentylenetetrazole in the native oocyte of Xenopus laevis.
1991,
Pubmed
,
Xenbase
Miledi,
Effects of defolliculation on membrane current responses of Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Miledi,
Membrane currents elicited by prostaglandins, atrial natriuretic factor and oxytocin in follicle-enclosed Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Pellmar,
Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance.
1977,
Pubmed
Prichard,
Pentylenetetrazol-induced increase in chloride permeability of leech neurons.
1971,
Pubmed
Speckmann,
Paroxysmal depolarization and changes in action potentials induced by pentylenetetrazol in isolated neurons of Helix pomatia.
1973,
Pubmed
Walden,
Membrane currents induced by pentylenetetrazol in identified neurons of Helix pomatia.
1988,
Pubmed