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XB-ART-17903
Curr Opin Genet Dev 1996 Aug 01;64:424-31. doi: 10.1016/s0959-437x(96)80063-3.
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Conservation of dorsal-ventral patterning in arthropods and chordates.

Ferguson EL .


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Dorsal-ventral patterning within the ectodermal and mesodermal germ layers of Drosophila and Xenopus embryos is specified by a system of genes that has been conserved over 500 million years of evolution. In both organisms, the activity of the TGF-beta family member DPP/BMP4 is antagonized by SOG/CHORDIN. A second Xenopus gene, noggin, has a similar biological activity to chordin. Analysis of the action of these genes indicate that Spemann's organizer promotes dorsal cell fates in Xenopus by antagonizing a ventralizing signal encoded by the Bmp4 gene.

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Species referenced: Xenopus
Genes referenced: bmp4 chrd nog