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XB-ART-17440
Dev Biol 1996 Nov 11;7391-2:335-8.
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pH-dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor.

Matsuda K , Hosie AM , Buckingham SD , Squire MD , Baylis HA , Sattelle DB .


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The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA declined rapidly during agonist application and a rebound response was observed on washout. By correcting the pH shift induced by these acid salts, responses more typical of GABA agonists were seen. Less striking pH-dependence was observed in the case of GABA responses.

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