Yeast 1997 Apr 01;135:441-7. doi: 10.1002/(SICI)1097-0061(199704)13:5<441::AID-YEA97>3.0.CO;2-O.

Meiotic inheritance of functional Gal80S gene product in Saccharomyces cerevisiae.

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Transcription factors inherited during meiosis play a crucial role directing subsequent gene activity. Factors of maternal origin have been shown to influence the pattern of early zygotic transcription during Drosophila and Xenopus embryogenesis. Nevertheless, little is known regarding the meiotic inheritance of the vast majority of transcription factors. In the case of yeast meiosis, for example, it is not yet known whether any of the multitude of transcription factors expressed in the diploid are transmitted to haploid spores in functional form. Here we use a GAL1-STE4 reporter whose activity is detectable in single living cells to identify a transcription factor inherited during sporulation in Saccharomyces cerevisiae. We show that functional Gal80S repressor is meiotically inherited at levels reflecting its expression in the diploid parent.

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