Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Dev Genes Evol
2005 Nov 01;21511:575-9. doi: 10.1007/s00427-005-0011-1.
Show Gene links
Show Anatomy links
Analysis of paralogous pontin and reptin gene expression during mouse development.
Chauvet S
,
Usseglio F
,
Aragnol D
,
Pradel J
.
???displayArticle.abstract???
Evolutionarily conserved from yeast to human, the paralogous DNA helicases Pontin (Pont) and Reptin (Rept) are simultaneously recruited in multi-protein chromatin complexes that function in different aspects of DNA metabolism (transcription, replication and repair). When assayed, the two proteins were found to be essential for viability and to play antagonistic roles, suggesting that the balance of Pont/Rept regulates epigenetic programmes critical for development. Consistent with this, the two helicases are provided in the same embryonic territories during Drosophila development. In Xenopus, while transcribed in the same regions early in embryogenesis, pont and rept adopt significantly different patterns afterwards. Here we report that the two genes follow highly resembling transcription patterns in mouse embryos, with prominent expression in limb buds and branchial arches, organs undergoing mesenchymal-epithelial interactions and in motoneurones from cranial and spinal regions. Thus, simultaneous expression during development appears to constitute another feature of the evolutionary conservation of pont and rept genes.
Bauer,
Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity.
2000, Pubmed
Bauer,
Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity.
2000,
Pubmed
Etard,
Expression of Xenopus homologs of the beta-catenin binding protein pontin52.
2000,
Pubmed
,
Xenbase
Feng,
TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling.
2003,
Pubmed
Garcès,
Responsiveness to neurturin of subpopulations of embryonic rat spinal motoneuron does not correlate with expression of GFR alpha 1 or GFR alpha 2.
2001,
Pubmed
Holt,
An evolutionarily conserved mediator of plant disease resistance gene function is required for normal Arabidopsis development.
2002,
Pubmed
Ikura,
Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.
2000,
Pubmed
Jessell,
Neuronal specification in the spinal cord: inductive signals and transcriptional codes.
2000,
Pubmed
Jónsson,
Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complex.
2004,
Pubmed
Kanemaki,
TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a.
1999,
Pubmed
Kim,
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.
2005,
Pubmed
Kurokawa,
A notable example of an evolutionary conserved gene: studies on a putative DNA helicase TIP49.
1999,
Pubmed
Lim,
The Saccharomyces cerevisiae RuvB-like protein, Tih2p, is required for cell cycle progression and RNA polymerase II-directed transcription.
2000,
Pubmed
Makino,
A rat RuvB-like protein, TIP49a, is a germ cell-enriched novel DNA helicase.
1999,
Pubmed
Mizuguchi,
ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.
2004,
Pubmed
Park,
BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation.
2002,
Pubmed
Rottbauer,
Reptin and pontin antagonistically regulate heart growth in zebrafish embryos.
2002,
Pubmed