XB-ART-16279
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
1997 Jul 01;1173:317-22. doi: 10.1016/s0742-8413(97)00004-2.
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Hormonal control of the in vitro uptake of [35S]sulfate by cartilage of Xenopus laevis tadpoles.
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The influence of various mammalian hormones and growth factors on the skeletal growth in the clawed toad was examined in vitro by monitoring the uptake of [35S]sulfate by tadpole's hindlimbs. Autoradiographic studies demonstrated that the isotope was mainly incorporated into the cartilage. Sulfate uptake was significantly stimulated by 13 nM insulin-like growth factor I (IGF-I) in all experiments. The effect of 13 nM IGF-II was statistically significant only in approximately 50% of the experiments. Insulin was inconsistently effective. A significant stimulation was found using 1300 nM insulin. Neither prolactin and growth hormone nor the thyroid hormones thyroxine and triiodothyronine affected the [35S]sulfate uptake in vitro. The results indicate that cartilage growth in amphibians is mainly stimulated by IGF-I and to a less extended by IGF-II like in mammals.
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Species referenced: Xenopus laevis
Genes referenced: ins prl.1