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XB-ART-15702
FEBS Lett 1997 Oct 27;4163:239-42.
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Translational control of terminal oligopyrimidine mRNAs requires a specific regulator.

Loreni F , Amaldi F .


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Terminal oligopyrimidine (TOP) mRNAs are a group of messengers translationally regulated according to the growth status of the cell. Two hypotheses have been proposed for the mechanism of the regulation: (i) there is a specific translational regulator which can reversibly alter TOP-mRNA structure, (ii) a component of the general translational apparatus can specifically affect the translation of TOP-mRNAs. To verify one of the two hypotheses we induced a partial inhibition of translation initiation in Xenopus cultured cells and analyzed the effect on TOP-mRNA translation. Our results suggest that a specific regulator is necessary to explain the translational control of these of mRNAs.

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???displayArticle.link??? FEBS Lett