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Synchronizing retinal activity in both eyes disrupts binocular map development in the optic tectum.
Brickley SG
,
Dawes EA
,
Keating MJ
,
Grant S
.
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Spatiotemporal correlations in the pattern of spontaneous and evoked retinal ganglion cell (RGC) activity are believed to influence the topographic organization of connections throughout the developing visual system. We have tested this hypothesis by examining the effects of interfering with these potential activity cues during development on the functional organization of binocular maps in the Xenopus frog optic tectum. Paired recordings combined with cross-correlation analyses demonstrated that exposing normal frogs to a continuous 1 Hz of stroboscopic illumination synchronized the firing of all three classes of RGC projecting to the tectum and induced similar patterns of temporally correlated activity across both lobes of the nucleus. Embryonic and eye-rotated larval animals were reared until early adulthood under equivalent stroboscopic conditions. The maps formed by each RGC class in the contralateral tectum showed normal topography and stratification after strobe rearing, but with consistently enlarged multiunit receptive fields. Maps of the ipsilateral eye, formed by crossed isthmotectal axons, showed significant disorder and misalignment with direct visual input from the retina, and in the eye-rotated animals complete compensatory reorientation of these maps usually induced by this procedure failed to occur. These findings suggest that refinement of retinal arbors in the tectum and the ability of crossed isthmotectal arbors to establish binocular convergence with these retinal afferents are disrupted when they all fire together. Our data thus provide direct experimental evidence that spatiotemporal activity patterns within and between the two eyes regulate the precision of their developing connections.
Aertsen,
Dynamics of neuronal firing correlation: modulation of "effective connectivity".
1989, Pubmed
Aertsen,
Dynamics of neuronal firing correlation: modulation of "effective connectivity".
1989,
Pubmed
Altmann,
Functional and neuronal binocularity in kittens raised with rapidly alternating monocular occlusion.
1987,
Pubmed
Berman,
An exuberant retinocollicular pathway in Siamese kittens: effects of competition and abnormal activity on its maturation.
1985,
Pubmed
Blasdel,
Degree of interocular synchrony required for maintenance of binocularity in kitten's visual cortex.
1979,
Pubmed
Carmignoto,
Activity-dependent decrease in NMDA receptor responses during development of the visual cortex.
1992,
Pubmed
Chung,
The structural and functional development of the retina in larval Xenopus.
1975,
Pubmed
,
Xenbase
Cline,
N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.
1987,
Pubmed
Cline,
NMDA receptor antagonists disrupt the retinotectal topographic map.
1989,
Pubmed
Cline,
NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection.
1990,
Pubmed
Constantine-Paton,
Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways.
1990,
Pubmed
Constantine-Paton,
The relationship between retinal axon ingrowth, terminal morphology, and terminal patterning in the optic tectum of the frog.
1983,
Pubmed
Cook,
A sharp retinal image increases the topographic precision of the goldfish retinotectal projection during optic nerve regeneration in stroboscopic light.
1987,
Pubmed
,
Xenbase
Cook,
Impaired refinement of the regenerated retinotectal projection of the goldfish in stroboscopic light: a quantitative WGA-HRP study.
1986,
Pubmed
Easter,
An evaluation of the hypothesis of shifting terminals in goldfish optic tectum.
1984,
Pubmed
Fisher,
Synaptic arrays of the inner plexiform layer in the developing retina of Xenopus.
1976,
Pubmed
,
Xenbase
Fraser,
Alteration of the retinotectal map in Xenopus by antibodies to neural cell adhesion molecules.
1984,
Pubmed
,
Xenbase
Fujisawa,
Mode of growth of retinal axons within the tectum of Xenopus tadpoles, and implications in the ordered neuronal connection between the retina and the tectum.
1987,
Pubmed
,
Xenbase
Gaze,
The relationship between retinal and tectal growth in larval Xenopus: implications for the development of the retino-tectal projection.
1979,
Pubmed
,
Xenbase
Gaze,
The evolution of the retinotectal map during development in Xenopus.
1974,
Pubmed
,
Xenbase
George,
Optic nerve terminal arborizations in the frog: shape and orientation inferred from electrophysiological measurements.
1974,
Pubmed
Goodman,
Developmental mechanisms that generate precise patterns of neuronal connectivity.
1993,
Pubmed
Grant,
Changing patterns of binocular visual connections in the intertectal system during development of the frog, Xenopus laevis. II. Abnormalities following early visual deprivation.
1989,
Pubmed
,
Xenbase
Grant,
Changing patterns of binocular visual connections in the intertectal system during development of the frog, Xenopus laevis. I. Normal maturational changes in response to changing binocular geometry.
1989,
Pubmed
,
Xenbase
Grant,
Normal maturation involves systematic changes in binocular visual connections in Xenopus laevis.
,
Pubmed
,
Xenbase
Grant,
Changing patterns of binocular visual connections in the intertectal system during development of the frog, Xenopus laevis. III. Modifications following early eye rotation.
1992,
Pubmed
,
Xenbase
Grant,
Ocular migration and the metamorphic and postmetamorphic maturation of the retinotectal system in Xenopus laevis: an autoradiographic and morphometric study.
1986,
Pubmed
,
Xenbase
Grigonis,
Organization of callosal connections in the visual cortex of the rabbit following neonatal enucleation, dark rearing, and strobe rearing.
1991,
Pubmed
Gustafsson,
Hippocampal long-lasting potentiation produced by pairing single volleys and brief conditioning tetani evoked in separate afferents.
1986,
Pubmed
Harris,
The effects of eliminating impulse activity on the development of the retinotectal projection in salamanders.
1980,
Pubmed
Hestrin,
Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse.
1992,
Pubmed
Holt,
Order in the initial retinotectal map in Xenopus: a new technique for labelling growing nerve fibres.
1983,
Pubmed
,
Xenbase
Keating,
The Critical Period for Experience-dependent Plasticity in a System of Binocular Visual Connections in Xenopus laevis: Its Temporal Profile and Relation to Normal Developmental Requirements.
1992,
Pubmed
,
Xenbase
Keating,
Visual deprivation and intertectal neuronal connexions in Xenopus laevis.
1975,
Pubmed
,
Xenbase
Keating,
Visual deprivation and the maturation of the retinotectal projection in Xenopus laevis.
1986,
Pubmed
,
Xenbase
Keating,
Visual experience and the maturation of the ipsilateral visuotectal projection in Xenopus laevis.
1987,
Pubmed
,
Xenbase
Levy,
Temporal contiguity requirements for long-term associative potentiation/depression in the hippocampus.
1983,
Pubmed
MATURANA,
Anatomy and physiology of vision in the frog (Rana pipiens).
1960,
Pubmed
Maffei,
Correlation in the discharges of neighboring rat retinal ganglion cells during prenatal life.
1990,
Pubmed
Meister,
Synchronous bursts of action potentials in ganglion cells of the developing mammalian retina.
1991,
Pubmed
O'Rourke,
Dynamic aspects of retinotectal map formation revealed by a vital-dye fiber-tracing technique.
1986,
Pubmed
,
Xenbase
O'Rourke,
Rapid remodeling of retinal arbors in the tectum with and without blockade of synaptic transmission.
1994,
Pubmed
,
Xenbase
Otani,
Long-term depression of naïve synapses in adult hippocampus induced by asynchronous synaptic activity.
1995,
Pubmed
Rauschecker,
Mechanisms of visual plasticity: Hebb synapses, NMDA receptors, and beyond.
1991,
Pubmed
Reh,
Eye-specific segregation requires neural activity in three-eyed Rana pipiens.
1985,
Pubmed
Sakaguchi,
The development of retinal ganglion cells in a tetraploid strain of Xenopus laevis: a morphological study utilizing intracellular dye injection.
1984,
Pubmed
,
Xenbase
Sanes,
Topographic maps and molecular gradients.
1993,
Pubmed
Scherer,
N-methyl-D-aspartate antagonists prevent interaction of binocular maps in Xenopus tectum.
1989,
Pubmed
,
Xenbase
Scherer,
Latency and temporal overlap of visually elicited contralateral and ipsilateral firing in Xenopus tectum during and after the critical period.
1991,
Pubmed
,
Xenbase
Schmidt,
Activity-driven sharpening of the retinotectal projection in goldfish: development under stroboscopic illumination prevents sharpening.
1993,
Pubmed
Schmidt,
Stroboscopic illumination and dark rearing block the sharpening of the regenerated retinotectal map in goldfish.
1985,
Pubmed
Sernagor,
Influence of spontaneous activity and visual experience on developing retinal receptive fields.
1996,
Pubmed
Stanton,
Associative long-term depression in the hippocampus induced by hebbian covariance.
1989,
Pubmed
Stiles,
Periodic and nonperiodic burst responses of frog (Rana pipiens) retinal ganglion cells.
1985,
Pubmed
Stuermer,
Development of the retinotectal projection in zebrafish embryos under TTX-induced neural-impulse blockade.
1990,
Pubmed
Udin,
Development of the nucleus isthmi in Xenopus, II: Branching patterns of contralaterally projecting isthmotectal axons during maturation of binocular maps.
1989,
Pubmed
,
Xenbase
Udin,
Plasticity in a central nervous pathway in xenopus: anatomical changes in the isthmotectal projection after larval eye rotation.
1981,
Pubmed
,
Xenbase
Udin,
Abnormal visual input leads to development of abnormal axon trajectories in frogs.
1983,
Pubmed
,
Xenbase
Udin,
Formation of topographic maps.
1988,
Pubmed
Witkovsky,
Photoreceptor thresholds and visual pigment levels in normal and vitamin A-deprived Xenopus tadpoles.
1976,
Pubmed
,
Xenbase
Wong,
Transient period of correlated bursting activity during development of the mammalian retina.
1993,
Pubmed
Yamagata,
Lamina-specific expression of adhesion molecules in developing chick optic tectum.
1995,
Pubmed
