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XB-ART-15312
FEBS Lett 1998 Feb 13;4231:15-8.
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Shared determinants of receptor binding for subtype selective, and dual endothelin-angiotensin antagonists on the AT1 angiotensin II receptor.

Dascal D , Nirula V , Lawus K , Yoo SE , Walsh TF , Sandberg K .


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Site-directed interspecies amino acid exchange was used to compare the binding determinants of a novel dual endothelial-angiotensin receptor ligand, L-746,072, with type-1 angiotensin receptor (AT1) selective antagonists on AT receptors expressed in COS cells. These studies suggest that residues on AT receptors which are non-conserved between amphibian and mammalian species play a greater role in subtype selective ligand recognition than for dual receptor ligands. These data also support the hypothesis that a common non-peptide binding site exists within transmembrane domains on peptidergic receptors.

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Species referenced: Xenopus laevis
Genes referenced: agtr1 atm