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XB-ART-15282
Ann N Y Acad Sci 1998 Feb 09;838:95-107.
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New technology for high-speed and high-resolution optical coherence tomography.

Fujimoto JG , Bouma B , Tearney GJ , Boppart SA , Pitris C , Southern JF , Brezinski ME .


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Optical coherence tomography (OCT) is an optical imaging technique that is capable of performing micron-scale, cross-sectional imaging of internal microstructure in biological systems. OCT is analogous to ultrasound B mode imaging except that it uses light rather than sound and performs imaging by measuring the back-scattered intensity of light from structures in tissue. We describe recent advances in OCT technology including the application of short pulse solid state lasers based on Ti: Al2O3 and Cr: Mg2SiO4 to enable high-resolution, high-speed imaging as well as the development of OCT catheter/endoscope delivery to permit imaging of internal organ systems. OCT enables the nonexcisional, in situ, real-time imaging of tissue microstructure and is thus a powerful and promising technique for optical biopsy.

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