Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-14533
Eur J Pharmacol 1998 May 29;3501:R5-6. doi: 10.1016/s0014-2999(98)00316-1.
Show Gene links Show Anatomy links

NF279: a novel potent and selective antagonist of P2X receptor-mediated responses.

Damer S , Niebel B , Czeche S , Nickel P , Ardanuy U , Schmalzing G , Rettinger J , Mutschler E , Lambrecht G .


???displayArticle.abstract???
8,8'-(Carbonylbis(imino-4, 1 -phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis(1,3, 5-naphthalenetrisulfonic acid) (NF279) antagonized P2X receptor-mediated contractions in rat vas deferens, evoked by alpha,beta-methylene ATP (10 microM; pIC50=5.71) without affecting responses mediated via alpha1A-adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and nicotinic receptors. The low inhibitory potency of NF279 on P2Y receptors in guinea-pig taenia coli (pA2=4.10) and at ecto-nucleotidases in folliculated Xenopus laevis oocytes (IC50 > 100 microM) indicates that NF279 is a novel specific and selective P2X receptor antagonist.

???displayArticle.pubmedLink??? 9683026
???displayArticle.link??? Eur J Pharmacol