XB-ART-14296
Biochim Biophys Acta
1998 Aug 14;13731:277-81.
Show Gene links
Show Anatomy links
Proton-coupled oligopeptide transport by rat renal cortical brush border membrane vesicles: a functional analysis using ACE inhibitors to determine the isoform of the transporter.
???displayArticle.abstract???
We demonstrate that the angiotensin-converting enzyme inhibitors enalapril and captopril inhibit the transport of D-Phe-L-Gln into PepT1-expressing Xenopus oocytes and into rat renal cortical brush border membrane vesicles (BBMV). The kinetics of inhibition are competitive. Enalapril and captopril are not substrates for PepT2 (Boll et al., Proc. Natl. Acad. Sci. 93 (1996) 284-289). Therefore we conclude that in rat renal cortical BBMV this neutral dipeptide is transported via PepT1.
???displayArticle.pubmedLink??? 9733984
???displayArticle.link??? Biochim Biophys Acta
Species referenced: Xenopus
Genes referenced: ace slc15a1 slc15a2 tbx2