Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-14145
Mech Dev 1998 Aug 01;761-2:57-66.
Show Gene links Show Anatomy links

High mobility group 1 (HMG1) protein in mouse preimplantation embryos.

Spada F , Brunet A , Mercier Y , Renard JP , Bianchi ME , Thompson EM .


???displayArticle.abstract???
High mobility group 1 protein (HMG1) has traditionally been considered a structural component of chromatin, possibly similar in function to histone H1. In fact, at the onset of Xenopus and Drosophila development, HMG1 appears to substitute for histone H1: HMG1 is abundant when histone H1 is absent after the midblastula transition histone H1 largely replaces HMG1. We show that in early mouse embryos the expression patterns of HMG1 and histone H1 are not complementary. Instead, HMG1 content increases after zygotic genome activation at the same time as histone H1. HMG1 does not remain associated to mitotic chromosomes either in embryos or somatic cells. These results argue against a shared structural role for HMG1 and histone H1 in mammalian chromatin.

???displayArticle.pubmedLink??? 9767109



Species referenced: Xenopus
Genes referenced: hmgb1