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XB-ART-14107
Neurosci Lett 1998 Sep 25;2542:81-4. doi: 10.1016/s0304-3940(98)00659-4.
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Function of GABA rho1 receptors is up-regulated by chronic GABA treatment in Xenopus oocytes.

Lin LH , Din TS , Pan YL .


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This study was aimed to investigate the effect of chronic gamma-aminobutyric acid (GABA) treatment on homomeric GABA rho1 receptors expressed in Xenopus oocytes. The rho1 mRNA-injected oocytes were incubated with 10 mM GABA for 2, 6, 24, 48 or 72 h, prior to the assessment of GABA-gated ion currents. The results showed that GABA exposure for more than 6 h dramatically enhanced the peak GABA-activated currents. In addition to current amplitude, the apparent GABA potency and cooperativity were significantly increased. The enhancement reached its plateau after a 24-h exposure. The up-regulation of GABA current amplitude was completely inhibited by cycloheximide, a translation inhibitor. This suggests that chronic GABA treatment may increase the translational activity of GABA rho1 subunit in Xenopus oocytes.

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