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XB-ART-14073
J Physiol Paris 1998 Jan 01;923-4:249-55. doi: 10.1016/s0928-4257(98)80028-4.
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Position effect variegations and brain-specific silencing in transgenic mice overexpressing human acetylcholinesterase variants.

Sternfeld M , Patrick JD , Soreq H .


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Position effect variegations as well as brain-specific silencing were observed in novel transgenic mouse pedigrees expressing human acetylcholinesterase (AChE) variants. Muscle AChE activities varied between 1.6- and 350-fold of control in these lines, one carrying insertion-inactivated InE6-AChE and two with 'readthrough' I4/E5 AChE, all under control of the ubiquitous CMV promoter. In contrast, brain AChE levels remained within a range of 1.5-fold over control, suggesting an upper limit of brain AChE which is compatible with life.

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Species referenced: Xenopus
Genes referenced: ache