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Antimicrob Agents Chemother
1998 Dec 01;4212:3320-4. doi: 10.1128/AAC.42.12.3320.
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In vitro activities of membrane-active peptides against gram-positive and gram-negative aerobic bacteria.
Giacometti A
,
Cirioni O
,
Greganti G
,
Quarta M
,
Scalise G
.
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Four peptides, cecropin P1, magainin II, indolicidin, and ranalexin, were evaluated against 202 clinical isolates of gram-positive and gram-negative aerobic bacteria by a microbroth dilution method. The gram-negative isolates were more susceptible to cecropin P1. Ranalexin was the most active compound against the gram-positive strains. The bactericidal activity of each peptide was equivalent to, or 1 dilution above, the MIC. In conclusion, the four peptides exhibited different in vitro activities and rapid time-dependent killing.
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