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EMBO J
1998 Dec 15;1724:7230-8. doi: 10.1093/emboj/17.24.7230.
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Fission yeast Csk1 is a CAK-activating kinase (CAKAK).
Hermand D
,
Pihlak A
,
Westerling T
,
Damagnez V
,
Vandenhaute J
,
Cottarel G
,
Mäkelä TP
.
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Cell cycle progression is dependent on the sequential activity of cyclin-dependent kinases (CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK-activating kinase (CAK). Two distinct CAK kinases have been described: in budding yeast Saccharomyces cerevisiae, the Cak1/Civ1 kinase is responsible for CAK activity. In several other species including human, Xenopus, Drosophila and fission yeast Schizosaccharomyces pombe, CAK has been identified as a complex homologous to CDK7-cyclin H (Mcs6-Mcs2 in fission yeast). Here we identify the fission yeast Csk1 kinase as an in vivo activating kinase of the Mcs6-Mcs2 CAK defining Csk1 as a CAK-activating kinase (CAKAK).
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