Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
EMBO J
1998 Dec 15;1724:7230-8. doi: 10.1093/emboj/17.24.7230.
Show Gene links
Show Anatomy links
Fission yeast Csk1 is a CAK-activating kinase (CAKAK).
Hermand D
,
Pihlak A
,
Westerling T
,
Damagnez V
,
Vandenhaute J
,
Cottarel G
,
Mäkelä TP
.
???displayArticle.abstract???
Cell cycle progression is dependent on the sequential activity of cyclin-dependent kinases (CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK-activating kinase (CAK). Two distinct CAK kinases have been described: in budding yeast Saccharomyces cerevisiae, the Cak1/Civ1 kinase is responsible for CAK activity. In several other species including human, Xenopus, Drosophila and fission yeast Schizosaccharomyces pombe, CAK has been identified as a complex homologous to CDK7-cyclin H (Mcs6-Mcs2 in fission yeast). Here we identify the fission yeast Csk1 kinase as an in vivo activating kinase of the Mcs6-Mcs2 CAK defining Csk1 as a CAK-activating kinase (CAKAK).
Booher,
Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase.
1987, Pubmed
Booher,
Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase.
1987,
Pubmed
Buck,
Identification of a cdk-activating kinase in fission yeast.
1995,
Pubmed
,
Xenbase
Cismowski,
KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity.
1995,
Pubmed
Damagnez,
Schizosaccharomyces pombe Mop1-Mcs2 is related to mammalian CAK.
1995,
Pubmed
De Bondt,
Crystal structure of cyclin-dependent kinase 2.
1993,
Pubmed
Desai,
Activation of human cyclin-dependent kinases in vitro.
1992,
Pubmed
Devault,
MAT1 ('menage à trois') a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.
1995,
Pubmed
,
Xenbase
Espinoza,
A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK.
1996,
Pubmed
Faye,
Rig2, a RING finger protein that interacts with the Kin28/Ccl1 CTD kinase in yeast.
1997,
Pubmed
Feaver,
Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits.
1997,
Pubmed
Feaver,
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK.
1994,
Pubmed
Fesquet,
Is Cdk7/cyclin H/MAT1 the genuine cdk activating kinase in cycling Xenopus egg extracts?
1997,
Pubmed
,
Xenbase
Fesquet,
The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.
1993,
Pubmed
,
Xenbase
Fisher,
Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase.
1995,
Pubmed
Fisher,
A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase.
1994,
Pubmed
Hengartner,
Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases.
1998,
Pubmed
Inamoto,
The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors.
1997,
Pubmed
Jeffrey,
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
1995,
Pubmed
Kaldis,
The Cdk-activating kinase (CAK) from budding yeast.
1996,
Pubmed
Kaldis,
Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities.
1998,
Pubmed
Ko,
p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.
1997,
Pubmed
Labbé,
p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Larochelle,
Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity.
1998,
Pubmed
Lee,
Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo.
1998,
Pubmed
Martinez,
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
1997,
Pubmed
,
Xenbase
Maundrell,
Thiamine-repressible expression vectors pREP and pRIP for fission yeast.
1993,
Pubmed
McNeil,
Activated transcription independent of the RNA polymerase II holoenzyme in budding yeast.
1998,
Pubmed
Molz,
cdc2 and the regulation of mitosis: six interacting mcs genes.
1989,
Pubmed
Molz,
Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity.
1993,
Pubmed
Moreno,
Molecular genetic analysis of fission yeast Schizosaccharomyces pombe.
1991,
Pubmed
Morgan,
Cyclin-dependent kinases: engines, clocks, and microprocessors.
1997,
Pubmed
Mäkelä,
A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription.
1995,
Pubmed
Mäkelä,
A cyclin associated with the CDK-activating kinase MO15.
1994,
Pubmed
,
Xenbase
Poon,
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.
1993,
Pubmed
,
Xenbase
Poon,
Cell cycle regulation of the p34cdc2/p33cdk2-activating kinase p40MO15.
1994,
Pubmed
,
Xenbase
Rossignol,
Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH.
1997,
Pubmed
Roy,
The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor.
1994,
Pubmed
Russo,
Structural basis of cyclin-dependent kinase activation by phosphorylation.
1996,
Pubmed
Serizawa,
Association of Cdk-activating kinase subunits with transcription factor TFIIH.
1995,
Pubmed
Shiekhattar,
Cdk-activating kinase complex is a component of human transcription factor TFIIH.
1995,
Pubmed
Shuttleworth,
p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Simanis,
The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation.
1986,
Pubmed
Simon,
KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28.
1986,
Pubmed
Solomon,
Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.
1992,
Pubmed
,
Xenbase
Solomon,
CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.
1993,
Pubmed
,
Xenbase
Tassan,
In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.
1995,
Pubmed
Thuret,
Civ1 (CAK in vivo), a novel Cdk-activating kinase.
1996,
Pubmed
Valay,
The KIN28 gene is required both for RNA polymerase II mediated transcription and phosphorylation of the Rpb1p CTD.
1995,
Pubmed
Valay,
The kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae.
1993,
Pubmed
Xu,
Biological activity of the mammalian RAP genes in yeast.
1990,
Pubmed
Yankulov,
Regulation of CDK7 substrate specificity by MAT1 and TFIIH.
1997,
Pubmed