XB-ART-13144
Biochim Biophys Acta
1999 Apr 14;14451:154-9.
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Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver1.
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To isolate the murine Na+/taurocholate cotransporting polypeptide (Ntcp), we screened a mouse liver cDNA library and identified Ntcp1, encoding a 362 amino acid protein and Ntcp2, encoding a 317 amino acid protein which had a shorter C-terminal end. Both isoforms mediated saturable Na+-dependent transport of taurocholate when expressed in Xenopus laevis oocytes. Analysis of the gene revealed that Ntcp2 is produced by alternative splicing where the last intron is retained.
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Species referenced: Xenopus laevis
Genes referenced: slc10a1