XB-ART-12573
Dev Biol
1999 Aug 07;8371-2:301-5.
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Nitric oxide activates a potassium current in olfactory receptor neurons from Caudiverbera caudiverbera and Xenopus laevis.
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The putative role of nitric oxide (NO) in the physiology of olfactory receptor neurons (ORNs) is controversial. Here we report that pulses of NO caused an outward current in voltage-clamped isolated olfactory neurons. The I-V relation of this effect, its sensitivity to charybdotoxin and its dependence on external potassium suggest that NO activates a K(+)-conductance. As blockers of soluble guanylyl cyclases failed to affect the current, we conclude that NO opens K(+)-channels in a cGMP-independent manner.
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