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Expression of immediate early genes, GATA-4, and Nkx-2.5 in adrenergic-induced cardiac hypertrophy and during regression in adult mice.
Saadane N
,
Alpert L
,
Chalifour LE
.
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Adrenoreceptor agonists induce a hypertrophic phenotype in vitro and in vivo. To investigate the molecular remodeling in chronic cardiac hypertrophy we infused adult male mice with vehicle. isoproterenol, phenylephrine or both agonists for 3, 7 or 14 days. All drugs increased cardiac mass. After minipump removal cardiac mass regressed to control levels within 7 days after PE and ISO treatment whereas ISO + PE treated hearts were incompletely regressed. ANF and beta-MHC, but not alpha-MHC, expression were increased by agonists at all time points. GATA-4, Nkx-2.5, Egr-1, c-jun and c-fos expression were increased after 3, 7 and 14 days of treatment. Expression was greatest after ISO+PE> >ISO>PE>vehicle infusion suggesting a synergistic effect of adrenoreceptor stimulation and indicating a greater effect of beta- than alpha-adrenergic action in vivo. After PE or ISO drug withdrawal the HW/BW was normal and Egr-1, c-jun, c-fos and GATA-4, but not Nkx2.5, expression dropped to control levels. HW/BW regression was incomplete after ISO+PE and elevated levels of Egr-1, c-jun and Nkx2.5 expression remained. A hydralazine-mediated reduction in blood pressure had no effect on the agonist-induced cardiac hypertrophy or gene expression. In conclusion, we found that continued agonist stimulation, and not blood pressure. is responsible for the maintained increase in gene expression. Further, we found the decrease in gene expression in the regression after drug withdrawal was gene specific.
Arceci,
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
1993, Pubmed
Arceci,
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
1993,
Pubmed
Ardati,
A nuclear pathway for alpha 1-adrenergic receptor signaling in cardiac cells.
1993,
Pubmed
Argentin,
Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells.
1994,
Pubmed
Bachiller,
Inducible expression of the proto-oncogene c-fos in transgenic mice.
1990,
Pubmed
Barka,
Proto-oncogene fos (c-fos) expression in the heart.
1987,
Pubmed
Boluyt,
Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart.
1995,
Pubmed
Brand,
Expression of nuclear proto-oncogenes in isoproterenol-induced cardiac hypertrophy.
1993,
Pubmed
Buu,
Norepinephrine in neonatal rat ventricular myocytes: association with the cell nucleus and binding to nuclear alpha 1- and beta-adrenergic receptors.
1993,
Pubmed
Böhm,
Beta-adrenergic neuroeffector mechanisms in cardiac hypertrophy of renin transgenic rats.
1994,
Pubmed
Böhm,
Dose-dependent dissociation of ACE-inhibitor effects on blood pressure, cardiac hypertrophy, and beta-adrenergic signal transduction.
1995,
Pubmed
Cassidy,
Effects of commonly used adrenergic agonists on left ventricular function and systemic vascular resistance in young piglets.
1997,
Pubmed
Chen,
Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements.
1996,
Pubmed
,
Xenbase
Chirgwin,
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
1979,
Pubmed
Durocher,
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors.
1997,
Pubmed
,
Xenbase
Durocher,
The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium.
1996,
Pubmed
,
Xenbase
Gandarillas,
Changes in expression of members of the fos and jun families and myc network during terminal differentiation of human keratinocytes.
1995,
Pubmed
Gashler,
Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors.
1995,
Pubmed
Golomb,
Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats.
1994,
Pubmed
Grépin,
A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription.
1994,
Pubmed
,
Xenbase
Gupta,
Egr-1, a serum-inducible zinc finger protein, regulates transcription of the rat cardiac alpha-myosin heavy chain gene.
1991,
Pubmed
Guyton,
Kidneys and fluids in pressure regulation. Small volume but large pressure changes.
1992,
Pubmed
Hannan,
Adrenergic agents, but not triiodo-L-thyronine induce c-fos and c-myc expression in the rat heart.
1991,
Pubmed
Herzig,
Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload.
1997,
Pubmed
Holder,
Molecular remodelling in hypertrophied hearts from polyomavirus large T-antigen transgenic mice.
1995,
Pubmed
Huang,
Reciprocal modulation between Sp1 and Egr-1.
1997,
Pubmed
Ip,
The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells.
1994,
Pubmed
Iwaki,
Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response.
1990,
Pubmed
John,
Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension.
1995,
Pubmed
Johnson,
A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.
1993,
Pubmed
Khachigian,
Inducible expression of Egr-1-dependent genes. A paradigm of transcriptional activation in vascular endothelium.
1997,
Pubmed
Kitsis,
Discordance between gene regulation in vitro and in vivo.
1992,
Pubmed
Kovacic-Milivojevic,
Selective regulation of the atrial natriuretic peptide gene by individual components of the activator protein-1 complex.
1996,
Pubmed
Kuo,
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.
1997,
Pubmed
Kurabayashi,
Functional identification of the transcriptional regulatory elements within the promoter region of the human ventricular myosin alkali light chain gene.
1990,
Pubmed
Laycock,
Effects of chronic norepinephrine administration on cardiac function in rats.
1995,
Pubmed
Laycock,
Captopril and norepinephrine-induced hypertrophy and haemodynamics in rats.
1996,
Pubmed
Lee,
Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A.
1995,
Pubmed
Lee,
Atrial natriuretic factor gene expression in ventricles of rats with spontaneous biventricular hypertrophy.
1988,
Pubmed
Liebermann,
MyD genes in negative growth control.
1998,
Pubmed
Liu,
Suppression of growth and transformation and induction of apoptosis by EGR-1.
1998,
Pubmed
Lord,
Proto-oncogenes of the fos/jun family of transcription factors are positive regulators of myeloid differentiation.
1993,
Pubmed
Lyons,
Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.
1995,
Pubmed
Milano,
Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.
1994,
Pubmed
Mils,
The proto-oncogene c-fos increases the sensitivity of keratinocytes to apoptosis.
1997,
Pubmed
Mitchell,
Equipotent antihypertensive agents variously affect pulsatile hemodynamics and regression of cardiac hypertrophy in spontaneously hypertensive rats.
1996,
Pubmed
Molkentin,
Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene.
1994,
Pubmed
Molkentin,
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.
1998,
Pubmed
Molkentin,
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
1997,
Pubmed
Osaki,
cAMP-mediated c-fos expression in pressure-overloaded acceleration of protein synthesis in adult rat heart.
1997,
Pubmed
Ostman-Smith,
Cardiac sympathetic nerves as the final common pathway in the induction of adaptive cardiac hypertrophy.
1981,
Pubmed
Panterne,
c-fos mRNA constitutive expression by mature human megakaryocytes.
1992,
Pubmed
Pollack,
Proto-oncogenes and the cardiovascular system.
1995,
Pubmed
Rauscher,
Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.
1988,
Pubmed
Reddy,
Effects of long-term hydralazine treatment on myocardial structure and expression of myosin isogenes in cardiac pressure overload in rats.
1996,
Pubmed
Rockman,
Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.
1997,
Pubmed
Rosenzweig,
Proximal regulatory domains of rat atrial natriuretic factor gene.
1991,
Pubmed
Rüther,
c-fos expression induces bone tumors in transgenic mice.
1989,
Pubmed
Saadane,
TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin.
1999,
Pubmed
Saez,
c-fos is required for malignant progression of skin tumors.
1995,
Pubmed
Sepulveda,
GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression.
1998,
Pubmed
,
Xenbase
Smeyne,
Continuous c-fos expression precedes programmed cell death in vivo.
1993,
Pubmed
Soonpaa,
Assessment of cardiomyocyte DNA synthesis during hypertrophy in adult mice.
1994,
Pubmed
Susic,
Angiotensin II increases left ventricular mass without affecting myosin isoform mRNAs.
1996,
Pubmed
Wang,
Bone and haematopoietic defects in mice lacking c-fos.
,
Pubmed
Zierhut,
Significance of myocardial alpha- and beta-adrenoceptors in catecholamine-induced cardiac hypertrophy.
1989,
Pubmed
van Bilsen,
Growth and hypertrophy of the heart: towards an understanding of cardiac specific and inducible gene expression.
1993,
Pubmed
