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Caffeine-sensitive calcium stores regulate synaptic transmission from retinal rod photoreceptors.
Krizaj D
,
Bao JX
,
Schmitz Y
,
Witkovsky P
,
Copenhagen DR
.
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We investigated the role of caffeine-sensitive intracellular stores in regulating intracellular calcium ([Ca(2+)](i)) and glutamatergic synaptic transmission from rod photoreceptors. Caffeine transiently elevated and then markedly depressed [Ca(2+)](i) to below prestimulus levels in rod inner segments and synaptic terminals. Concomitant with the depression was a reduction of glutamate release and a hyperpolarization of horizontal cells, neurons postsynaptic to rods. Caffeine did not affect the rods' membrane potentials indicating that caffeine likely acted via some mechanism(s) other than a voltage-dependent deactivation of the calcium channels. Most of caffeine's depressive action on [Ca(2+)](i), on glutamate release, and on I(Ca) in rods can be attributed to calcium release from stores: (1) caffeine's actions on [Ca(2+)](i) and I(Ca) were reduced by intracellular BAPTA and barium substitution for calcium, (2) other nonxanthine store-releasing compounds, such as thymol and chlorocresol, also depressed [Ca(2+)](i), and (3) the magnitude of [Ca(2+)](i) depression depended on basal [Ca(2+)](i) before caffeine. We propose that caffeine-released calcium reduces I(Ca) in rods by an as yet unidentified intracellular signaling mechanism. To account for the depression of [Ca(2+)](i) below rest levels and the increased fall rate of [Ca(2+)](i) with higher basal calcium, we also propose that caffeine-evoked calcium release from stores activates a calcium transporter that, via sequestration into stores or extrusion, lowers [Ca(2+)](i) and suppresses glutamate release. The effects of store-released calcium reported here operate at physiological calcium concentrations, supporting a role in regulating synaptic signaling in vivo.
Adachi-Akahane,
Cross-signaling between L-type Ca2+ channels and ryanodine receptors in rat ventricular myocytes.
1996, Pubmed
Adachi-Akahane,
Cross-signaling between L-type Ca2+ channels and ryanodine receptors in rat ventricular myocytes.
1996,
Pubmed
Akaike,
Voltage-dependent activation of potassium current in Helix neurones by endogenous cellular calcium.
1983,
Pubmed
Bader,
A voltage-clamp study of the light response in solitary rods of the tiger salamander.
1979,
Pubmed
Bader,
Voltage-activated and calcium-activated currents studied in solitary rod inner segments from the salamander retina.
1982,
Pubmed
Barnes,
Ionic channels of the inner segment of tiger salamander cone photoreceptors.
1989,
Pubmed
Berridge,
Neuronal calcium signaling.
1998,
Pubmed
Bezprozvanny,
Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum.
1991,
Pubmed
Cahill,
Light-sensitive melatonin synthesis by Xenopus photoreceptors after destruction of the inner retina.
1992,
Pubmed
,
Xenbase
Capovilla,
The effect of phosphodiesterase inhibitors on the electrical activity of toad rods.
1983,
Pubmed
Cervetto,
The effects of phosphodiesterase inhibitors and lanthanum ions on the light-sensitive current of toad retinal rods.
1986,
Pubmed
Cheek,
The caffeine-sensitive Ca2+ store in bovine adrenal chromaffin cells; an examination of its role in triggering secretion and Ca2+ homeostasis.
1990,
Pubmed
Copenhagen,
Release of endogenous excitatory amino acids from turtle photoreceptors.
1989,
Pubmed
Corey,
The calcium current in inner segments of rods from the salamander (Ambystoma tigrinum) retina.
1984,
Pubmed
Cseresnyés,
Release-activated Ca2+ transport in neurons of frog sympathetic ganglia.
1997,
Pubmed
Ehrlich,
The pharmacology of intracellular Ca(2+)-release channels.
1994,
Pubmed
Fain,
Sensitivity of toad rods: Dependence on wave-length and background illumination.
1976,
Pubmed
Fosse,
A bioluminescence method for the measurement of L-glutamate: applications to the study of changes in the release of L-glutamate from lateral geniculate nucleus and superior colliculus after visual cortex ablation in rats.
1986,
Pubmed
Friel,
A caffeine- and ryanodine-sensitive Ca2+ store in bullfrog sympathetic neurones modulates effects of Ca2+ entry on [Ca2+]i.
1992,
Pubmed
Gan,
Depolarization and activation of dihydropyridine-sensitive Ca2+ channels stimulate inositol phosphate accumulation in photoreceptor-enriched chick retinal cell cultures.
1997,
Pubmed
Garaschuk,
Release and sequestration of calcium by ryanodine-sensitive stores in rat hippocampal neurones.
1997,
Pubmed
Golovina,
Spatially and functionally distinct Ca2+ stores in sarcoplasmic and endoplasmic reticulum.
1997,
Pubmed
Gray-Keller,
The calcium feedback signal in the phototransduction cascade of vertebrate rods.
1994,
Pubmed
Grynkiewicz,
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
1985,
Pubmed
Haack,
Calcium-dependent inactivation of L-type calcium channels in planar lipid bilayers.
1994,
Pubmed
Henkart,
Similarity of junctions between plasma membranes and endoplasmic reticulum in muscle and neurons.
1976,
Pubmed
Hernández-Cruz,
Properties of the ryanodine-sensitive release channels that underlie caffeine-induced Ca2+ mobilization from intracellular stores in mammalian sympathetic neurons.
1995,
Pubmed
Hua,
Characteristics of Ca2+ release induced by Ca2+ influx in cultured bullfrog sympathetic neurones.
1993,
Pubmed
Hughes,
The action of caffeine on inward barium current through voltage-dependent calcium channels in single rabbit ear artery cells.
1990,
Pubmed
Katz,
Tetrodotoxin-resistant electric activity in presynaptic terminals.
1969,
Pubmed
Kramer,
Effects of caffeine on intracellular calcium, calcium current and calcium-dependent potassium current in anterior pituitary GH3 cells.
1994,
Pubmed
Krijnse-Locker,
The organization of the endoplasmic reticulum and the intermediate compartment in cultured rat hippocampal neurons.
1995,
Pubmed
Krizaj,
Compartmentalization of calcium extrusion mechanisms in the outer and inner segments of photoreceptors.
1998,
Pubmed
Krizaj,
The effects of L-glutamate, AMPA, quisqualate, and kainate on retinal horizontal cells depend on adaptational state: implications for rod-cone interactions.
1994,
Pubmed
,
Xenbase
Kwan,
Uptake and intracellular sequestration of divalent cations in resting and methacholine-stimulated mouse lacrimal acinar cells. Dissociation by Sr2+ and Ba2+ of agonist-stimulated divalent cation entry from the refilling of the agonist-sensitive intracellular pool.
1990,
Pubmed
Lara,
A caffeine-sensitive Ca2+ store modulates K+-evoked secretion in chromaffin cells.
1997,
Pubmed
Lipscombe,
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.
1988,
Pubmed
Llano,
Calcium-induced calcium release in cerebellar Purkinje cells.
1994,
Pubmed
MacLeish,
Use of a monoclonal antibody as a substrate for mature neurons in vitro.
1983,
Pubmed
Marrion,
Release of intracellular calcium and modulation of membrane currents by caffeine in bull-frog sympathetic neurones.
1992,
Pubmed
Matthews,
Neurotransmitter release.
1996,
Pubmed
McNulty,
Caffeine-stimulated Ca2+ release from the intracellular stores of hepatocytes is not mediated by ryanodine receptors.
1993,
Pubmed
McPherson,
The brain ryanodine receptor: a caffeine-sensitive calcium release channel.
1991,
Pubmed
Meldolesi,
The endoplasmic reticulum Ca2+ store: a view from the lumen.
1998,
Pubmed
Mercurio,
Smooth endoplasmic reticulum and other agranular reticulum in frog retinal photoreceptors.
1982,
Pubmed
Minke,
The roles of trp and calcium in regulating photoreceptor function in Drosophila.
1996,
Pubmed
Neher,
Vesicle pools and Ca2+ microdomains: new tools for understanding their roles in neurotransmitter release.
1998,
Pubmed
Neher,
The use of fura-2 for estimating Ca buffers and Ca fluxes.
1995,
Pubmed
Nehlig,
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects.
1992,
Pubmed
O'Neill,
The role of [Ca2+]i and [Ca2+] sensitization in the caffeine contracture of rat myocytes: measurement of [Ca2+]i and [caffeine]i.
1990,
Pubmed
Orkand,
Effects of low doses of caffeine on [Ca2+]i in voltage-clamped snail (Helix aspersa) neurones.
1995,
Pubmed
Pacaud,
Opposing effects of noradrenaline on the two classes of voltage-dependent calcium channels of single vascular smooth muscle cells in short-term primary culture.
1987,
Pubmed
Peng,
Localization of the inositol 1,4,5-trisphosphate receptor in synaptic terminals in the vertebrate retina.
1991,
Pubmed
Pessah,
Bastadins relate ryanodine-sensitive and -insensitive Ca2+ efflux pathways in skeletal SR and BC3H1 cells.
1997,
Pubmed
Pozzan,
Molecular and cellular physiology of intracellular calcium stores.
1994,
Pubmed
Przywara,
Barium-induced exocytosis is due to internal calcium release and block of calcium efflux.
1993,
Pubmed
Ratto,
The concentration of cytosolic free calcium in vertebrate rod outer segments measured with fura-2.
1988,
Pubmed
Rieke,
Asynchronous transmitter release: control of exocytosis and endocytosis at the salamander rod synapse.
1996,
Pubmed
Sah,
Ca(2+)-activated K+ currents underlying the afterhyperpolarization in guinea pig vagal neurons: a role for Ca(2+)-activated Ca2+ release.
1991,
Pubmed
Schilling,
Characterization of the bradykinin-stimulated calcium influx pathway of cultured vascular endothelial cells. Saturability, selectivity, and kinetics.
1989,
Pubmed
Schmid,
Voltage-dependent InsP3-insensitive calcium channels in membranes of pancreatic endoplasmic reticulum vesicles.
1990,
Pubmed
Schmitz,
Dependence of photoreceptor glutamate release on a dihydropyridine-sensitive calcium channel.
1997,
Pubmed
,
Xenbase
Schmitz,
Glutamate release by the intact light-responsive photoreceptor layer of the Xenopus retina.
1996,
Pubmed
,
Xenbase
Schuhmann,
Intracellular Ca2+ inhibits smooth muscle L-type Ca2+ channels by activation of protein phosphatase type 2B and by direct interaction with the channel.
1997,
Pubmed
Sham,
Ca2+ release-induced inactivation of Ca2+ current in rat ventricular myocytes: evidence for local Ca2+ signalling.
1997,
Pubmed
Sitsapesan,
Mechanisms of caffeine activation of single calcium-release channels of sheep cardiac sarcoplasmic reticulum.
1990,
Pubmed
Somlyo,
Elemental distribution in Rana pipiens retinal rods: quantitative electron probe analysis.
1985,
Pubmed
Sridhar,
Unique postsynaptic signaling at the hair cell efferent synapse permits calcium to evoke changes on two time scales.
1997,
Pubmed
Tse,
Local Ca2+ release from internal stores controls exocytosis in pituitary gonadotrophs.
1997,
Pubmed
Tsien,
Multiple types of neuronal calcium channels and their selective modulation.
1988,
Pubmed
Tsien,
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.
1980,
Pubmed
Ungar,
Uptake of calcium by the endoplasmic reticulum of the frog photoreceptor.
1984,
Pubmed
Walton,
Ryanodine and inositol trisphosphate receptors coexist in avian cerebellar Purkinje neurons.
1991,
Pubmed
Witkovsky,
Gain of rod to horizontal cell synaptic transfer: relation to glutamate release and a dihydropyridine-sensitive calcium current.
1997,
Pubmed
,
Xenbase
Zorzato,
Chlorocresol: an activator of ryanodine receptor-mediated Ca2+ release.
1993,
Pubmed
de Leon,
Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels.
1995,
Pubmed
