XB-ART-12109
Cell Biol Int
1999 Jan 01;231:73-80. doi: 10.1006/cbir.1998.0318.
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Protein kinase C affects reformation of endothelial junctions in xenopus XTH-2 cells.
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Endothelial cells can reversibly be forced to suppress the formation of endothelial junctions (EJ) by cultivation in a low calcium medium. The authors localized vinculin and cadherin as marker proteins of EJ and actin as a cytoskeletal component by fluorescence microscopy, and used this cell model to study the reformation of endothelial junctions under conditions of activation and inhibition of protein kinase C (PKC). Inhibition of PKC by H-7 leads to an acceleration of EJ reformation, while constitutive activation by TPA inhibits the reformation process.
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Species referenced: Xenopus
Genes referenced: actl6a