Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-11997
Science 1999 Nov 12;2865443:1362-5.
Show Gene links Show Anatomy links

The protein kinase p90 rsk as an essential mediator of cytostatic factor activity.

Bhatt RR , Ferrell JE .


???displayArticle.abstract???
Persistent activation of p42 mitogen-activated protein kinase (p42 MAPK) during mitosis induces a "cytostatic factor" arrest, the arrest responsible for preventing the parthenogenetic activation of unfertilized eggs. The protein kinase p90 Rsk is a substrate of p42 MAPK; thus, the role of p90 Rsk in p42 MAPK-induced mitotic arrest was examined. Xenopus laevis egg extracts immunodepleted of Rsk lost their capacity to undergo mitotic arrest in response to activation of the Mos-MEK-1-p42 MAPK cascade of protein kinases. Replenishing Rsk-depleted extracts with catalytically competent Rsk protein restored the ability of the extracts to undergo mitotic arrest. Rsk appears to be essential for cytostatic factor arrest.

???displayArticle.pubmedLink??? 10558991
???displayArticle.link??? Science
???displayArticle.grants??? [+]

Species referenced: Xenopus laevis
Genes referenced: cdk20 cip2a mapk1 mos rps6ka1 rps6ka3

References :
Nebreda, Perspectives: signal transduction. Cell survival demands some Rsk. 1999, Pubmed