Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-11793
Pediatr Nephrol 1999 Nov 01;139:806-11.
Show Gene links Show Anatomy links

Ontogeny of renal sulfate transporters: postnatal mRNA and protein expression.

Markovich D , Fogelis TS .


???displayArticle.abstract???
Renal reabsorption of inorganic sulfate changes during growth and development. We have studied the expression of two proximal tubular sulfate transporters, NaS(i)-1 and sat-1, during postnatal maturation. Both NaS(i)-1 and sat-1 mRNA levels increase postnatally, peaking at day 14, with a maximal tenfold increase in NaS(i)-1 and sat-1 mRNA levels compared with day 1. A similar age-dependent increase was observed for sodium-dependent and sodium-independent sulfate uptakes by injection of rat kidney mRNA into Xenopus oocytes. Western blot analysis of renal membranes from rats aged day 1 to day 77 showed no significant changes for NaS(i)-1 protein, whereas sat-1 protein levels paralleled mRNA expression, increasing from day 1 to day 14, followed by a decrease in protein levels thereafter. For NaSi-1 protein expression, translational or posttranslational mechanisms may maintain equal numbers of sulfate proteins on proximal tubular membranes during maturation, whereas sat-1 protein levels are in close agreement with mRNA changes. This is the first study to look at the ontogeny of renal sulfate transporter (NaS(i)-1 and sat-1) expression during postnatal maturation.

???displayArticle.pubmedLink??? 10603126
???displayArticle.link??? Pediatr Nephrol


Species referenced: Xenopus laevis
Genes referenced: slc13a1 slc26a1