Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Blood
2006 Mar 01;1075:1908-15. doi: 10.1182/blood-2005-05-1814.
Show Gene links
Show Anatomy links
Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome.
MacDonald BA
,
Sund M
,
Grant MA
,
Pfaff KL
,
Holthaus K
,
Zon LI
,
Kalluri R
.
???displayArticle.abstract???
Goodpasture syndrome is an autoimmune vascular disease associated with kidney and lung failure, with pathogenic circulating autoantibodies targeted to a set of discontinuous epitope sequences within the noncollagenous domain-1 (NC1) of the alpha3 chain of type IV collagen (alpha3(IV)NC1), the Goodpasture autoantigen. We demonstrate that basement membrane extracted NC1 domain preparations from Caenorhabditis elegans, Drosophila melanogaster, and Danio rerio do not bind Goodpasture autoantibodies, while Xenopus laevis, chicken, mouse and human alpha3(IV)NC1 domains bind autoantibodies. The alpha3(IV) chain is not present in C elegans and Drosophila melanogaster, but is first detected in the Danio rerio. Interestingly, native Danio rerio alpha3(IV)NC1 does not bind Goodpasture autoantibodies. Next, we cloned, sequenced, and generated recombinant Danio rerio alpha3(IV)NC1 domain. In contrast to recombinant human alpha3(IV)NC1 domain, there was complete absence of autoantibody binding to recombinant Danio rerio alpha3(IV)NC1. Three-dimensional molecular modeling from existing x-ray coordinates of human NC1 domain suggest that evolutionary alteration of electrostatic charge and polarity due to the emergence of critical serine, aspartic acid, and lysine residues, accompanied by the loss of asparagine and glutamine, contributes to the emergence of the 2 major Goodpasture epitopes on the human alpha3(IV)NC1 domain, as it evolved from the Danio rerio over 450 million years.
Bolton,
Epitope spreading and autoimmune glomerulonephritis in rats induced by a T cell epitope of Goodpasture's antigen.
2005, Pubmed
Bolton,
Epitope spreading and autoimmune glomerulonephritis in rats induced by a T cell epitope of Goodpasture's antigen.
2005,
Pubmed
Borza,
Pathogenesis of Goodpasture syndrome: a molecular perspective.
2003,
Pubmed
Borza,
The goodpasture autoantigen. Identification of multiple cryptic epitopes on the NC1 domain of the alpha3(IV) collagen chain.
2000,
Pubmed
Boute,
Type IV collagen in sponges, the missing link in basement membrane ubiquity.
1996,
Pubmed
Cecchini,
Evidence for a type-IV-related collagen in Drosophila melanogaster. Evolutionary constancy of the carboxyl-terminal noncollagenous domain.
1987,
Pubmed
Charytan,
An unusual case of pulmonary-renal syndrome associated with defects in type IV collagen composition and anti-glomerular basement membrane autoantibodies.
2005,
Pubmed
Chen,
Immunodominant epitopes of alpha3(IV)NC1 induce autoimmune glomerulonephritis in rats.
2003,
Pubmed
Cosgrove,
Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome.
1996,
Pubmed
Couser,
Anti-GBM antibody-induced proteinuria in isolated perfused rat kidney.
1985,
Pubmed
David,
Hydrophobic amino acid residues are critical for the immunodominant epitope of the Goodpasture autoantigen. A molecular basis for the cryptic nature of the epitope.
2001,
Pubmed
Dean,
Experimental autoimmune Goodpasture's disease: a pathogenetic role for both effector cells and antibody in injury.
2005,
Pubmed
Derry,
Analysis of T cell responses to the autoantigen in Goodpasture's disease.
1995,
Pubmed
Exposito,
Evolution of collagens.
2002,
Pubmed
Fisher,
Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes.
1997,
Pubmed
Gunnarsson,
Molecular properties of the Goodpasture epitope.
2000,
Pubmed
Guo,
The two Caenorhabditis elegans basement membrane (type IV) collagen genes are located on separate chromosomes.
1989,
Pubmed
Hellmark,
Point mutations of single amino acids abolish ability of alpha3 NC1 domain to elicit experimental autoimmune glomerulonephritis in rats.
2003,
Pubmed
Hellmark,
Goodpasture disease. Characterization of a single conformational epitope as the target of pathogenic autoantibodies.
1999,
Pubmed
Hudson,
Alport's syndrome, Goodpasture's syndrome, and type IV collagen.
2003,
Pubmed
Hudson,
Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis.
1993,
Pubmed
Kahsai,
Seminiferous tubule basement membrane. Composition and organization of type IV collagen chains, and the linkage of alpha3(IV) and alpha5(IV) chains.
1997,
Pubmed
Kalluri,
Basement membranes: structure, assembly and role in tumour angiogenesis.
2003,
Pubmed
Kalluri,
Goodpasture syndrome. Localization of the epitope for the autoantibodies to the carboxyl-terminal region of the alpha 3(IV) chain of basement membrane collagen.
1991,
Pubmed
Kalluri,
The alpha 3 chain of type IV collagen induces autoimmune Goodpasture syndrome.
1994,
Pubmed
Kalluri,
Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice.
1997,
Pubmed
Kalluri,
Goodpasture syndrome.
1999,
Pubmed
Kalluri,
Assembly of type IV collagen. Insights from alpha3(IV) collagen-deficient mice.
2000,
Pubmed
Lerner,
The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis.
1999,
Pubmed
Levy,
Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression.
2001,
Pubmed
Liu,
Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies.
2002,
Pubmed
Maeshima,
Distinct antitumor properties of a type IV collagen domain derived from basement membrane.
2000,
Pubmed
Maeshima,
Identification of the anti-angiogenic site within vascular basement membrane-derived tumstatin.
2001,
Pubmed
Merkel,
Autoreactive T-cells in Goodpasture's syndrome recognize the N-terminal NC1 domain on alpha 3 type IV collagen.
1996,
Pubmed
Miner,
Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches.
1994,
Pubmed
Netzer,
The goodpasture autoantigen. Mapping the major conformational epitope(s) of alpha3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain.
1999,
Pubmed
Ninomiya,
Differential expression of two basement membrane collagen genes, COL4A6 and COL4A5, demonstrated by immunofluorescence staining using peptide-specific monoclonal antibodies.
1995,
Pubmed
Robertson,
Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis.
2005,
Pubmed
Ryan,
Sequence analysis of the 'Goodpasture antigen' of mammals.
1998,
Pubmed
Saito,
Differential expression of mouse alpha5(IV) and alpha6(IV) collagen genes in epithelial basement membranes.
2000,
Pubmed
Than,
The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link.
2002,
Pubmed
Walters,
Glomerular T cells are of restricted clonality and express multiple CDR3 motifs across different Vbeta T-cell receptor families in experimental autoimmune glomerulonephritis.
2004,
Pubmed
Wu,
A self T cell epitope induces autoantibody response: mechanism for production of antibodies to diverse glomerular basement membrane antigens.
2004,
Pubmed
Yasothornsrikul,
viking: identification and characterization of a second type IV collagen in Drosophila.
1997,
Pubmed
