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Mol Cell Biol
2000 Feb 01;203:1089-94. doi: 10.1128/MCB.20.3.1089-1094.2000.
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Targeted disruption of mouse fibroblast activation protein.
Niedermeyer J
,
Kriz M
,
Hilberg F
,
Garin-Chesa P
,
Bamberger U
,
Lenter MC
,
Park J
,
Viertel B
,
Püschner H
,
Mauz M
,
Rettig WJ
,
Schnapp A
.
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Human fibroblast activation protein (FAP), a member of the serine prolyl oligopeptidase family, is a type II cell surface glycoprotein selectively expressed by fibroblastic cells in areas of active tissue remodeling, such as the embryonic mesenchyme, areas of wound healing, the gravid uterus, and the reactive stroma of epithelial cancers. Homologues of FAP have been identified in the mouse and Xenopus laevis. FAP is a dual-specificity enzyme that acts as a dipeptidyl peptidase and collagenase in vitro. To explore the role of FAP in vivo, Fap(-/-) mice were generated by homologous recombination. RNase protection analysis and reverse transcription-PCR confirmed the absence of full-length Fap transcripts in mouse embryonic tissues. No FAP protein was detected in Fap(-/-) animals by immunohistochemistry, and no FAP-specific dipeptidyl peptidase activity was found. We report that Fap(-/-) mice are fertile, show no overt developmental defects, and have no general change in cancer susceptibility.
Brown,
The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis.
1996, Pubmed,
Xenbase
Brown,
The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis.
1996,
Pubmed
,
Xenbase
Danø,
Cancer invasion and tissue remodeling--cooperation of protease systems and cell types.
1999,
Pubmed
Garin-Chesa,
Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.
1990,
Pubmed
Hahn,
Creation of human tumour cells with defined genetic elements.
1999,
Pubmed
Kinzler,
Lessons from hereditary colorectal cancer.
1996,
Pubmed
Levy,
Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis.
1999,
Pubmed
Morimoto,
The structure and function of CD26 in the T-cell immune response.
1998,
Pubmed
Nagy,
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.
1993,
Pubmed
Niedermeyer,
Mouse fibroblast-activation protein--conserved Fap gene organization and biochemical function as a serine protease.
1998,
Pubmed
Niedermeyer,
Mouse fibroblast activation protein: molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers.
1997,
Pubmed
Ohtani,
Stromal reaction in cancer tissue: pathophysiologic significance of the expression of matrix-degrading enzymes in relation to matrix turnover and immune/inflammatory reactions.
1998,
Pubmed
Park,
Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts.
1999,
Pubmed
,
Xenbase
Rettig,
Cell-surface glycoproteins of human sarcomas: differential expression in normal and malignant tissues and cultured cells.
1988,
Pubmed
Rettig,
Fibroblast activation protein: purification, epitope mapping and induction by growth factors.
1994,
Pubmed
Rudolph-Owen,
Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1-deficient mice.
1997,
Pubmed
Rønnov-Jessen,
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction.
1996,
Pubmed
Scanlan,
Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.
1994,
Pubmed
Tybulewicz,
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.
1991,
Pubmed
Yancopoulos,
Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border.
1998,
Pubmed
