Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-11476
FEBS Lett 2000 Jan 28;4662-3:287-91.
Show Gene links Show Anatomy links

p97 ATPase, an ATPase involved in membrane fusion, interacts with DNA unwinding factor (DUF) that functions in DNA replication.

Yamada T , Okuhara K , Iwamatsu A , Seo H , Ohta K , Shibata T , Murofushi H .


???displayArticle.abstract???
DNA unwinding factor (DUF) unwinds duplex DNA and is supposed to function in DNA replication in Xenopus egg extracts. Here we report the isolation and analysis of a DUF-interacting factor. By immunoprecipitation, we found that p97 ATPase (p97) interacts with DUF in Xenopus egg extracts. This interaction was confirmed by the in vitro binding of purified p97 with DUF. When sperm chromatin was added to Xenopus egg extracts to construct nuclei active in DNA replication, p97 was incorporated into the nuclei. These data suggest that the complex of DUF and p97 may function in DNA replication.

???displayArticle.pubmedLink??? 10682845
???displayArticle.link??? FEBS Lett


Species referenced: Xenopus
Genes referenced: eif4g2 vcp