XB-ART-11376
Chem Pharm Bull (Tokyo)
2000 Feb 01;482:278-80. doi: 10.1248/cpb.48.278.
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Synthesis and pharmacological activity of O-(5-isoxazolyl)-L-serine.
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A novel isoxazole derivative, O-(5-isoxazolyl)-L-serine (OIS, 1), was synthesized by a Mitsunobu reaction of isoxazolin-5-one (4) with N-Boc-L-serine tert-butyl ester (5) and subsequent deprotection of the coupling product. Its structure was elucidated by spectroscopic analyses. The pharmacological activity of 1 was also examined with cloned glutamate receptors and transporters using a Xenopus oocyte-expressing system showing substrate activity on an excitatory amino acid carrier 1 (EAAC 1) as a glutamate transporter.
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Species referenced: Xenopus
Genes referenced: boc tert