XB-ART-1132
Neuroreport
2005 Nov 28;1617:1955-8. doi: 10.1097/01.wnr.0000186595.64458.ad.
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Influence of the point mutation alpha-1-H101R on the assembly of gamma-aminobutyric acid type A receptors.
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The point mutation H101R in the alpha1-subunit of gamma-aminobutyric acid type A receptors is known to abolish effects by benzodiazepine diazepam. This mutation and homologous mutations in other alpha-subunits have been used to quantify receptor pentamers containing two different alpha-subunit isoforms, and to study the role of alpha-subunit isoforms in the response of mice to diazepam. Both types of study assumed implicitly or explicitly that this mutation strongly affects assembly with the gamma2-subunit. Here, we investigated the assembly properties of mutated in comparison with wild-type subunits, and demonstrate that alpha1H101R has similar assembly properties as wild-type alpha1.
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