Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Calcitonin gene-related peptide suppresses hair cell responses to mechanical stimulation in the Xenopus lateral line organ.
Bailey GP
,
Sewell WF
.
???displayArticle.abstract???
The presence of calcitonin gene-related peptide (CGRP) in the efferent fibers of virtually every hair cell organ studied suggests it may serve some fundamental but heretofore unknown role in control of hair cell function. We examined the effects of CGRP on spontaneous and stimulus-evoked discharge patterns in an in vitro preparation of the lateral line organ of Xenopus laevis. Discharge patterns were determined by sinusoidally displacing the cupula with a glass micropipette driven with a piezoelectric device while recording afferent fiber activity. All afferent fibers had characteristic frequencies of 16-32 Hz. Responses synchronized to cupular displacements as small as 20 nm. CGRP suppressed responses of the lateral line organ to displacement while increasing spontaneous discharge rate. In the presence of CGRP, stimulus-response curves were shifted 10 dB toward higher displacement levels. The suppression of stimulus-evoked responses suggests a function for CGRP as an efferent neurotransmitter that is similar to that of cholinergic efferent transmission in other hair cell organs. The 10 dB shift toward larger displacements makes it comparable in magnitude with the effects of electrical stimulation of efferents in the mammalian cochlea. This suggests a significant role for CGRP in efferent modulation of the output of this mechanosensory organ.
Adams,
A possible neurotransmitter role for CGRP in a hair-cell sensory organ.
1987, Pubmed,
Xenbase
Adams,
A possible neurotransmitter role for CGRP in a hair-cell sensory organ.
1987,
Pubmed
,
Xenbase
Aiyar,
Calcitonin gene-related peptide receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+ signaling pathways.
1999,
Pubmed
Art,
Synaptic hyperpolarization and inhibition of turtle cochlear hair cells.
1984,
Pubmed
Boyle,
Efferent vestibular system in the toadfish: action upon horizontal semicircular canal afferents.
1990,
Pubmed
Elepfandt,
Processing of wave patterns in the lateral line system parallels to auditory processing.
1988,
Pubmed
,
Xenbase
Elgoyhen,
Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells.
1994,
Pubmed
,
Xenbase
Flock,
Inhibition by efferent nerve fibres: action on hair cells and afferent synaptic transmission in the lateral line canal organ of the burbot Lota lota.
1976,
Pubmed
Flock,
Neurotransmitter synthesis in inner ear and lateral line sense organs.
1974,
Pubmed
Fuchs,
Synaptic transmission at vertebrate hair cells.
1996,
Pubmed
Gifford,
Effects of crossed-olivocochlear-bundle stimulation on cat auditory nerve fiber responses to tones.
1983,
Pubmed
Giniatullin,
Calcitonin gene-related peptide rapidly downregulates nicotinic receptor function and slowly raises intracellular Ca2+ in rat chromaffin cells in vitro.
1999,
Pubmed
Goldberg,
Efferent vestibular system in the squirrel monkey: anatomical location and influence on afferent activity.
1980,
Pubmed
Harris,
Input-output characteristics of the lateral-line sense organs of Xenopus laevis.
1966,
Pubmed
,
Xenbase
Hellmann,
Neuroanatomical and histochemical evidence for the presence of common lateral line and inner ear efferents and of efferents to the basilar papilla in a frog, Xenopus laevis.
1996,
Pubmed
,
Xenbase
Huang,
Ca2+-induced Ca2+ release involved in positive inotropic effect mediated by CGRP in ventricular myocytes.
1999,
Pubmed
Ishikawa,
Effect of calcitonin gene-related peptide on cytosolic free Ca2+ level in vascular smooth muscle.
1993,
Pubmed
Johnson,
The relationship between spike rate and synchrony in responses of auditory-nerve fibers to single tones.
1980,
Pubmed
Kroese,
Frequency response of the lateral-line organ of Xenopus laevis.
1978,
Pubmed
,
Xenbase
Liberman,
Efferent synapses in the inner hair cell area of the cat cochlea: an electron microscopic study of serial sections.
1980,
Pubmed
Liberman,
Afferent and efferent innervation of the cat cochlea: quantitative analysis with light and electron microscopy.
1990,
Pubmed
Martin,
The dependence of calcium-activated potassium currents on membrane potential.
1992,
Pubmed
Ohno,
Coexistence of acetylcholine and calcitonin gene-related peptide in the vestibular efferent neurons in the rat.
1991,
Pubmed
Roberts,
Coexistence of calcitonin gene-related peptide and choline acetyltransferase in eel efferent neurons.
1994,
Pubmed
Roberts,
Localization of calcium signals by a mobile calcium buffer in frog saccular hair cells.
1994,
Pubmed
Russell,
The pharmacology of efferent synapses in the lateral-line system of Xenopus laevis.
1971,
Pubmed
,
Xenbase
Russell,
Influence of efferent fibres on a receptor.
1968,
Pubmed
Safieddine,
Choline acetyltransferase, glutamate decarboxylase, tyrosine hydroxylase, calcitonin gene-related peptide and opioid peptides coexist in lateral efferent neurons of rat and guinea-pig.
1997,
Pubmed
Sewell,
Neuroactive substances in inner ear extracts.
1987,
Pubmed
,
Xenbase
Sewell,
Effects of calcitonin gene-related peptide and efferent nerve stimulation on afferent transmission in the lateral line organ.
1991,
Pubmed
,
Xenbase
Shelton,
The lateral line system at metamorphosis in Xenopus laevis (Daudin).
1970,
Pubmed
,
Xenbase
Shigemoto,
Muscarinic agonists and ATP increase the intracellular Ca2+ concentration in chick cochlear hair cells.
1990,
Pubmed
Sliwinska-Kowalska,
CGRP-like immunoreactivity in the guinea pig organ of Corti: a light and electron microscopy study.
1989,
Pubmed
Sridhar,
A novel cholinergic "slow effect" of efferent stimulation on cochlear potentials in the guinea pig.
1995,
Pubmed
Takeda,
Localization and fine structure of calcitonin gene-related peptide (CGRP)-like immunoreactive nerve fibres in the organ of Corti of guinea pigs by immunohistochemistry.
1987,
Pubmed
Vetter,
Chemically distinct rat olivocochlear neurons.
1991,
Pubmed
Wackym,
Immunoelectron microscopy of the human inner ear.
1990,
Pubmed