Persson M , Stamataki D , te Welscher P , Andersson E , Böse J , Rüther U , Ericson J , Briscoe J .

Aza-Blanc, Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. 1997, Pubmed

Aza-Blanc, Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. 1997, Pubmed
Aza-Blanc, Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. 2000, Pubmed
Bai, Gli1 can rescue the in vivo function of Gli2. 2001, Pubmed , Xenbase
Barth, Bmp activity establishes a gradient of positional information throughout the entire neural plate. 1999, Pubmed
Briscoe, Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. 1999, Pubmed
Briscoe, A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube. 2001, Pubmed
Briscoe, Specification of neuronal fates in the ventral neural tube. 2001, Pubmed
Briscoe, A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. 2000, Pubmed
Böse, Pallister-Hall syndrome phenotype in mice mutant for Gli3. 2002, Pubmed , Xenbase
Büscher, The XtJ allele generates a Gli3 fusion transcript. 1998, Pubmed , Xenbase
Chiang, Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. 1996, Pubmed
Dai, Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. 1999, Pubmed , Xenbase
Ding, Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. 1998, Pubmed , Xenbase
Dyer, Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. 2001, Pubmed
Eggenschwiler, Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. 2001, Pubmed
Ericson, Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. 1992, Pubmed , Xenbase
Ericson, Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. 1997, Pubmed , Xenbase
Ericson, Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. 1996, Pubmed
Goodrich, Altered neural cell fates and medulloblastoma in mouse patched mutants. 1997, Pubmed
Gritli-Linde, The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. 2001, Pubmed
Gross, Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. 2002, Pubmed
HAMBURGER, A series of normal stages in the development of the chick embryo. 1951, Pubmed
Hardcastle, The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. 1998, Pubmed , Xenbase
Hui, A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. 1993, Pubmed
Hui, Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development. 1994, Pubmed
Hynes, The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types. 2000, Pubmed
Ingham, Hedgehog signaling in animal development: paradigms and principles. 2001, Pubmed
Ingham, Transducing Hedgehog: the story so far. 1998, Pubmed
Jessell, Neuronal specification in the spinal cord: inductive signals and transcriptional codes. 2000, Pubmed
Jia, Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. 2002, Pubmed , Xenbase
Krishnan, Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. 1997, Pubmed
Lee, The specification of dorsal cell fates in the vertebrate central nervous system. 1999, Pubmed
Lee, Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. 1997, Pubmed , Xenbase
Lewis, Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. 2001, Pubmed , Xenbase
Liem, Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites. 2000, Pubmed
Litingtung, Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. 2002, Pubmed
Litingtung, Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. 2000, Pubmed , Xenbase
Liu, Carboxy-terminally truncated Gli3 proteins associate with Smads. 1998, Pubmed , Xenbase
Mansouri, Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord. 1998, Pubmed
Marigo, Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. 1996, Pubmed , Xenbase
Matise, Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. 1998, Pubmed
Maynard, High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion. 2002, Pubmed , Xenbase
Mo, Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. 1997, Pubmed , Xenbase
Motoyama, Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. 1998, Pubmed , Xenbase
Muhr, Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. 2001, Pubmed
Mullor, Wnt signals are targets and mediators of Gli function. 2001, Pubmed
Muroyama, Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. 2002, Pubmed
Méthot, Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. 1999, Pubmed
Méthot, An absolute requirement for Cubitus interruptus in Hedgehog signaling. 2001, Pubmed
Müller, The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord. 2002, Pubmed
Nguyen, Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway. 2000, Pubmed
Novitch, Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. 2001, Pubmed
Ohlmeyer, Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. , Pubmed
Pabst, NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos. 2000, Pubmed
Park, Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. 2000, Pubmed , Xenbase
Patten, Opponent activities of Shh and BMP signaling during floor plate induction in vivo. 2002, Pubmed
Pavletich, Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. 1993, Pubmed
Pearse, Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis. 2001, Pubmed
Pierani, Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. 2001, Pubmed
Pierani, A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. 1999, Pubmed
Price, Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. 2002, Pubmed
Qiu, Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development. 1998, Pubmed
Robbins, Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. 1997, Pubmed
Ruiz i Altaba, Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. 1998, Pubmed , Xenbase
Ruppert, The GLI-Kruppel family of human genes. 1988, Pubmed
Sasaki, Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. 1999, Pubmed , Xenbase
Sasaki, A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. 1997, Pubmed , Xenbase
Schaeren-Wiemers, A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. 1993, Pubmed
Tanabe, Specification of motor neuron identity by the MNR2 homeodomain protein. 1998, Pubmed , Xenbase
Theil, Gli3 is required for Emx gene expression during dorsal telencephalon development. 1999, Pubmed , Xenbase
Timmer, BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors. 2002, Pubmed
Tole, Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). 2000, Pubmed , Xenbase
Vallstedt, Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification. 2001, Pubmed
Wang, Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. 2000, Pubmed , Xenbase
Wichterle, Directed differentiation of embryonic stem cells into motor neurons. 2002, Pubmed
Wijgerde, A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. 2002, Pubmed , Xenbase
Yamada, Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate. 1993, Pubmed
te Welscher, Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. 2002, Pubmed
von Mering, Distinct and regulated activities of human Gli proteins in Drosophila. 1999, Pubmed , Xenbase