Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Mol Cell Biol
2001 Feb 01;214:1360-9. doi: 10.1128/MCB.21.4.1360-1369.2001.
Show Gene links
Show Anatomy links
The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos.
Satijn DP
,
Hamer KM
,
den Blaauwen J
,
Otte AP
.
???displayArticle.abstract???
Polycomb group (PcG) proteins form multimeric protein complexes which are involved in the heritable stable repression of genes. Previously, we identified two distinct human PcG protein complexes. The EED-EZH protein complex contains the EED and EZH2 PcG proteins, and the HPC-HPH PcG complex contains the HPC, HPH, BMI1, and RING1 PcG proteins. Here we show that YY1, a homolog of the Drosophila PcG protein pleiohomeotic (Pho), interacts specificially with the human PcG protein EED but not with proteins of the HPC-HPH PcG complex. Since YY1 and Pho are DNA-binding proteins, the interaction between YY1 and EED provides a direct link between the chromatin-associated EED-EZH PcG complex and the DNA of target genes. To study the functional significance of the interaction, we expressed the Xenopus homologs of EED and YY1 in Xenopus embryos. Both Xeed and XYY1 induce an ectopic neural axis but do not induce mesodermal tissues. In contrast, members of the HPC-HPH PcG complex do not induce neural tissue. The exclusive, direct neuralizing activity of both the Xeed and XYY1 proteins underlines the significance of the interaction between the two proteins. Our data also indicate a role for chromatin-associated proteins, such as PcG proteins, in Xenopus neural induction.
Brown,
The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1.
1998, Pubmed
Brown,
The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1.
1998,
Pubmed
Conlon,
Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm.
1996,
Pubmed
,
Xenbase
Donohoe,
Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality.
1999,
Pubmed
Gould,
Functions of mammalian Polycomb group and trithorax group related genes.
1997,
Pubmed
Gunster,
Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.
1997,
Pubmed
Gutjahr,
The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family.
1995,
Pubmed
Harland,
Formation and function of Spemann's organizer.
1997,
Pubmed
Jones,
The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression.
1998,
Pubmed
Kanno,
mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity.
1995,
Pubmed
Kingston,
Repression and activation by multiprotein complexes that alter chromatin structure.
1996,
Pubmed
Kintner,
Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction.
1987,
Pubmed
,
Xenbase
Knecht,
Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm.
1995,
Pubmed
,
Xenbase
Mohun,
Cell type-specific activation of actin genes in the early amphibian embryo.
,
Pubmed
,
Xenbase
Ng,
A Drosophila ESC-E(Z) protein complex is distinct from other polycomb group complexes and contains covalently modified ESC.
2000,
Pubmed
Otte,
Protein kinase C mediates neural induction in Xenopus laevis.
1988,
Pubmed
,
Xenbase
Otte,
Neural induction is mediated by cross-talk between the protein kinase C and cyclic AMP pathways.
1989,
Pubmed
,
Xenbase
Otte,
Protein kinase C isozymes have distinct roles in neural induction and competence in Xenopus.
1992,
Pubmed
,
Xenbase
Otte,
Expression and potential functions of G-protein alpha subunits in embryos of Xenopus laevis.
1992,
Pubmed
,
Xenbase
Pirrotta,
PcG complexes and chromatin silencing.
1997,
Pubmed
Pisaneschi,
Characterization of FIII/YY1, a Xenopus laevis conserved zinc-finger protein binding to the first exon of L1 and L14 ribosomal protein genes.
1994,
Pubmed
,
Xenbase
Reijnen,
Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other.
1995,
Pubmed
,
Xenbase
Rupp,
Xenopus embryos regulate the nuclear localization of XMyoD.
1994,
Pubmed
,
Xenbase
Satijn,
RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.
1997,
Pubmed
Satijn,
Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis.
1997,
Pubmed
,
Xenbase
Satijn,
RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity.
1999,
Pubmed
Satijn,
Polycomb group protein complexes: do different complexes regulate distinct target genes?
1999,
Pubmed
Schumacher,
Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond.
1997,
Pubmed
Sewalt,
Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.
1998,
Pubmed
Shao,
Stabilization of chromatin structure by PRC1, a Polycomb complex.
1999,
Pubmed
Shi,
Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein.
1991,
Pubmed
Shumacher,
Positional cloning of a global regulator of anterior-posterior patterning in mice.
1996,
Pubmed
Simon,
Locking in stable states of gene expression: transcriptional control during Drosophila development.
1995,
Pubmed
Smith,
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos.
1992,
Pubmed
,
Xenbase
Steinbach,
Somatic linker histones cause loss of mesodermal competence in Xenopus.
1997,
Pubmed
,
Xenbase
Strouboulis,
Transcriptional repression by XPc1, a new Polycomb homolog in Xenopus laevis embryos, is independent of histone deacetylase.
1999,
Pubmed
,
Xenbase
Struhl,
Early role of the esc+ gene product in the determination of segments in Drosophila.
1982,
Pubmed
Thomas,
Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?
1999,
Pubmed
Tie,
The Drosophila Polycomb Group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites.
1998,
Pubmed
Wilson,
Vertebrate neural induction: inducers, inhibitors, and a new synthesis.
1997,
Pubmed
,
Xenbase
Yang,
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.
1996,
Pubmed
Zaraisky,
A novel homeobox gene expressed in the anterior neural plate of the Xenopus embryo.
1992,
Pubmed
,
Xenbase
van Lohuizen,
Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging.
1991,
Pubmed
van der Vlag,
Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation.
1999,
Pubmed
von Dassow,
Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene.
1993,
Pubmed
,
Xenbase
