XB-ART-50560
Development
2015 May 01;1429:1555-60. doi: 10.1242/dev.121590.
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Animal models for studying neural crest development: is the mouse different?
Barriga EH
,
Trainor PA
,
Bronner M
,
Mayor R
.
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The neural crest is a uniquely vertebrate cell type and has been well studied in a number of model systems. Zebrafish, Xenopus and chick embryos largely show consistent requirements for specific genes in early steps of neural crest development. By contrast, knockouts of homologous genes in the mouse often do not exhibit comparable early neural crest phenotypes. In this Spotlight article, we discuss these species-specific differences, suggest possible explanations for the divergent phenotypes in mouse and urge the community to consider these issues and the need for further research in complementary systems.
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???displayArticle.grants??? [+]
HD037105 NICHD NIH HHS , MR/J000655/1 Medical Research Council , R01 DE016082 NIDCR NIH HHS, MR/M010465/1 Medical Research Council , DE024157 NIDCR NIH HHS, DE 016082 NIDCR NIH HHS, Wellcome Trust , MRC_MR/M010465/1 Medical Research Council , R01 DE024157 NIDCR NIH HHS, P01 HD037105 NICHD NIH HHS
References [+] :
Akiyama,
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.
2004, Pubmed
Akiyama, Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. 2004, Pubmed
Aoki, Sox10 regulates the development of neural crest-derived melanocytes in Xenopus. 2003, Pubmed , Xenbase
Aybar, Early induction of neural crest cells: lessons learned from frog, fish and chick. 2002, Pubmed , Xenbase
Aybar, Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. 2003, Pubmed , Xenbase
Banerjee, A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration. 2011, Pubmed
Barembaum, Identification and dissection of a key enhancer mediating cranial neural crest specific expression of transcription factor, Ets-1. 2013, Pubmed
Basch, Specification of the neural crest occurs during gastrulation and requires Pax7. 2006, Pubmed
Betancur, Assembling neural crest regulatory circuits into a gene regulatory network. 2010, Pubmed
Betancur, A Sox10 enhancer element common to the otic placode and neural crest is activated by tissue-specific paralogs. 2011, Pubmed
Betancur, Genomic code for Sox10 activation reveals a key regulatory enhancer for cranial neural crest. 2010, Pubmed , Xenbase
Bhatt, Signals and switches in Mammalian neural crest cell differentiation. 2013, Pubmed
Bronner, Development and evolution of the neural crest: an overview. 2012, Pubmed , Xenbase
Bronner, Formation and migration of neural crest cells in the vertebrate embryo. 2012, Pubmed
Bronner-Fraser, Effects of antibodies against N-cadherin and N-CAM on the cranial neural crest and neural tube. 1992, Pubmed
Carmona-Fontaine, Contact inhibition of locomotion in vivo controls neural crest directional migration. 2008, Pubmed , Xenbase
Chai, Recent advances in craniofacial morphogenesis. 2006, Pubmed
Chakrabarti, Frequency of gamma-Ray Induced Specific Locus and Recessive Lethal Mutations in Mature Germ Cells of the Zebrafish, BRACHYDANIO RERIO. 1983, Pubmed
Cheung, The transcriptional control of trunk neural crest induction, survival, and delamination. 2005, Pubmed
Cheung, Neural crest development is regulated by the transcription factor Sox9. 2003, Pubmed
Conway, Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant. 1997, Pubmed
Cornell, Delta/Notch signaling promotes formation of zebrafish neural crest by repressing Neurogenin 1 function. 2002, Pubmed
Danielian, Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. 1998, Pubmed
De Calisto, Essential role of non-canonical Wnt signalling in neural crest migration. 2005, Pubmed , Xenbase
Driever, A genetic screen for mutations affecting embryogenesis in zebrafish. 1996, Pubmed
Dupé, Retinoic acid receptors exhibit cell-autonomous functions in cranial neural crest cells. 2009, Pubmed
Echtermeyer, Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4. 2001, Pubmed
Elkouby, Mesodermal Wnt signaling organizes the neural plate via Meis3. 2010, Pubmed , Xenbase
Endo, Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development. 2002, Pubmed
Fairchild, FoxD3 regulates cranial neural crest EMT via downregulation of tetraspanin18 independent of its functions during neural crest formation. 2014, Pubmed
Fantauzzo, PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways. 2014, Pubmed
Frank, An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. 2002, Pubmed
García-Castro, Ectodermal Wnt function as a neural crest inducer. 2002, Pubmed
Glavic, Interplay between Notch signaling and the homeoprotein Xiro1 is required for neural crest induction in Xenopus embryos. 2004, Pubmed , Xenbase
Greco, Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. 1996, Pubmed
Haffter, The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. 1996, Pubmed
Hamblet, Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. 2002, Pubmed
He, A critical role for PDGFRα signaling in medial nasal process development. 2013, Pubmed
Hong, Transcription factor AP2 epsilon (Tfap2e) regulates neural crest specification in Xenopus. 2014, Pubmed , Xenbase
Ikeya, Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression. 2001, Pubmed
Ikeya, Wnt signalling required for expansion of neural crest and CNS progenitors. 1997, Pubmed
Ishii, Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. 2005, Pubmed
Jiang, The Slug gene is not essential for mesoderm or neural crest development in mice. 1998, Pubmed
Jiang, Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. 1996, Pubmed
Knight, lockjaw encodes a zebrafish tfap2a required for early neural crest development. 2003, Pubmed
LaBonne, Snail-related transcriptional repressors are required in Xenopus for both the induction of the neural crest and its subsequent migration. 2000, Pubmed , Xenbase
LaBonne, Neural crest induction in Xenopus: evidence for a two-signal model. 1998, Pubmed , Xenbase
Lee, A local Wnt-3a signal is required for development of the mammalian hippocampus. 2000, Pubmed
Lewis, Reiterated Wnt signaling during zebrafish neural crest development. 2004, Pubmed
Lewis, The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. 2013, Pubmed
Lister, Zebrafish Foxd3 is required for development of a subset of neural crest derivatives. 2006, Pubmed
Liu, Distinct activities of Msx1 and Msx3 in dorsal neural tube development. 2004, Pubmed
Luo, Induction of neural crest in Xenopus by transcription factor AP2alpha. 2003, Pubmed , Xenbase
Luo, N-cadherin is required for neural crest remodeling of the cardiac outflow tract. 2006, Pubmed
Maczkowiak, The Pax3 and Pax7 paralogs cooperate in neural and neural crest patterning using distinct molecular mechanisms, in Xenopus laevis embryos. 2010, Pubmed , Xenbase
Majumdar, Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. 2003, Pubmed
Martínez-Morales, FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk. 2011, Pubmed
Matthews, Wnt11r is required for cranial neural crest migration. 2008, Pubmed , Xenbase
Matthews, Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA. 2008, Pubmed , Xenbase
Mayor, The neural crest. 2013, Pubmed , Xenbase
Mayor, Role of FGF and noggin in neural crest induction. 1997, Pubmed , Xenbase
McMahon, The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. 1992, Pubmed
Mead, Notch pathway regulation of neural crest cell development in vivo. 2012, Pubmed
Minchin, Sequential actions of Pax3 and Pax7 drive xanthophore development in zebrafish neural crest. 2008, Pubmed
Monsoro-Burq, Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction. 2005, Pubmed , Xenbase
Mori-Akiyama, Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. 2003, Pubmed
Murray, Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. 2006, Pubmed
Nakagawa, Neural crest emigration from the neural tube depends on regulated cadherin expression. 1998, Pubmed
Nakaya, Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. 2005, Pubmed
Nieto, Control of cell behavior during vertebrate development by Slug, a zinc finger gene. 1994, Pubmed
Nikitina, Gene regulatory networks that control the specification of neural-crest cells in the lamprey. 2009, Pubmed
Nikitina, Dissecting early regulatory relationships in the lamprey neural crest gene network. 2008, Pubmed
O'Donnell, Functional analysis of Sox8 during neural crest development in Xenopus. 2006, Pubmed , Xenbase
Ota, Hagfish embryology with reference to the evolution of the neural crest. 2007, Pubmed
Parker, A Hox regulatory network of hindbrain segmentation is conserved to the base of vertebrates. 2014, Pubmed
Patthey, Wnt-regulated temporal control of BMP exposure directs the choice between neural plate border and epidermal fate. 2009, Pubmed
Peng, Making designer mutants in model organisms. 2014, Pubmed
Phillips, Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development. 2006, Pubmed
Piloto, Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration. 2010, Pubmed
Pohl, Overexpression of the transcriptional repressor FoxD3 prevents neural crest formation in Xenopus embryos. 2001, Pubmed , Xenbase
Pryor, Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals. 2014, Pubmed , Xenbase
Rios, Neural crest regulates myogenesis through the transient activation of NOTCH. 2011, Pubmed
Rodríguez-Marí, Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development. 2005, Pubmed
Roehl, Zebrafish pea3 and erm are general targets of FGF8 signaling. 2001, Pubmed
Saint-Jeannet, Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a. 1997, Pubmed , Xenbase
Sakai, Treacher Collins syndrome: unmasking the role of Tcof1/treacle. 2009, Pubmed
Sasai, Requirement of FoxD3-class signaling for neural crest determination in Xenopus. 2001, Pubmed , Xenbase
Sauka-Spengler, Ancient evolutionary origin of the neural crest gene regulatory network. 2007, Pubmed
Schorle, Transcription factor AP-2 essential for cranial closure and craniofacial development. 1996, Pubmed
Shi, Snail2 controls mesodermal BMP/Wnt induction of neural crest. 2011, Pubmed , Xenbase
Simões-Costa, Insights into neural crest development and evolution from genomic analysis. 2013, Pubmed
Simões-Costa, Establishing neural crest identity: a gene regulatory recipe. 2015, Pubmed
Sock, Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8. 2001, Pubmed
Spokony, The transcription factor Sox9 is required for cranial neural crest development in Xenopus. 2002, Pubmed , Xenbase
Steventon, Genetic network during neural crest induction: from cell specification to cell survival. 2005, Pubmed
Steventon, Differential requirements of BMP and Wnt signalling during gastrulation and neurulation define two steps in neural crest induction. 2009, Pubmed , Xenbase
Stewart, Zebrafish foxd3 is selectively required for neural crest specification, migration and survival. 2006, Pubmed
Sun, Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6. 2008, Pubmed
Takada, Wnt-3a regulates somite and tailbud formation in the mouse embryo. 1994, Pubmed
Taneyhill, Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest. 2007, Pubmed
Teng, Requirement for Foxd3 in the maintenance of neural crest progenitors. 2008, Pubmed
Theveneau, Collective chemotaxis requires contact-dependent cell polarity. 2010, Pubmed , Xenbase
Trainor, Specification of neural crest cell formation and migration in mouse embryos. 2005, Pubmed
Trainor, Facial dysostoses: Etiology, pathogenesis and management. 2013, Pubmed
Tribulo, Regulation of Msx genes by a Bmp gradient is essential for neural crest specification. 2003, Pubmed , Xenbase
Vadasz, Pax7 is regulated by cMyb during early neural crest development through a novel enhancer. 2013, Pubmed
Villanueva, Posteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction. 2002, Pubmed , Xenbase
Yan, A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. 2005, Pubmed
Yoshikawa, Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. 1997, Pubmed
Zhang, Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. 1996, Pubmed
van Amerongen, Knockout mouse models to study Wnt signal transduction. 2006, Pubmed