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XB-ART-742
Dev Cell 2006 Feb 01;102:154-6. doi: 10.1016/j.devcel.2006.01.009.
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Tolloid gets Sizzled competing with Chordin.

Mullins MC .


Abstract
The enigma of Sizzled, a secreted Frizzled-related protein, has been resolved in a recent study from the De Robertis lab ( [in the January 13 issue of Cell]). Sizzled, although homologous to other Wnt antagonists, does not function as such, nor does it function within a Wnt signaling pathway. Remarkably it functions as an antagonist of BMP signaling, competing with Chordin for binding to its inhibitor a Tolloid-related metalloprotease. This competition protects Chordin from cleavage, thus allowing it to bind and limit BMP signaling.

PubMed ID: 16459293
Article link: Dev Cell


Species referenced: Xenopus
Genes referenced: bmp1 chrd pdlim7 szl

References :
Lee, Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases. 2006, Pubmed, Xenbase