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XB-ART-16750
Cell 1997 Mar 21;886:747-56. doi: 10.1016/s0092-8674(00)81921-2.
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Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.

Leyns L , Bouwmeester T , Kim SH , Piccolo S , De Robertis EM .


Abstract
Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD mRNA and leads to embryos with enlarged heads and shortened trunks. Frzb-1 antagonizes the effects of Xwnt-8 ectopic expression in a non-cell-autonomous manner. Cultured cells transfected with a membrane-tethered form of Wnt-1 bind epitope-tagged Frzb-1 in the 10(-10) M range. The results strengthen the view that the Spemann organizer is a source of secreted inhibitory factors.

PubMed ID: 9118218
PMC ID: PMC3061830
Article link: Cell
Grant support: [+]

Species referenced: Xenopus
Genes referenced: chrd frzb gsc lhx1 myod1 nog sia1 wnt1 wnt8a


Article Images: [+] show captions
References [+] :
Bhanot, A new member of the frizzled family from Drosophila functions as a Wingless receptor. 1996, Pubmed